{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:27:55Z","timestamp":1745468875181,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Clinical trials have shown that benefits of endovascular recanalization (EVT) for acute ischemic stroke patients with sizable penumbral tissues seems plausible even beyond 6 h after their last seen normal (LSN). Persistency of ischemic penumbra remains unclear in delayed periods. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; From a prospective stroke registry database, we identified 111 acute ischemic stroke patients who had internal carotid artery or middle cerebral artery occlusion with baseline National Institutes of Health Stroke Scale scores \u22656 points and arrived 6\u201312 h after LSN. Baseline information and functional outcomes were prospectively collected as a clinical registry. Attending physicians made treatment decisions for EVT based on the current guidelines and institutional protocols. MR image parameters, including the volume of diffusion-restricted lesions and mapping of the \u00adhypoperfused area, were quantified using automated commercial software. Binary logistic regression analysis models, with modified Rankin Scale (mRS) scores of 0\u20131 at 3\u00a0months after stroke included as a dependent variable, were constructed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Between 6 and 12 h after onset, 58% had a mismatch ratio of \u22651.8 at baseline and 42% had favorable imaging profiles as determined by DEFUSE 2 study. After 9 h, there was a mismatch ratio of \u22651.8 in 47 and 38% favorable profiles. EVT was performed in 54% of cases. A 3-month mRS score of 0\u20131 was found in 19% (25% in EVT and 12% in medical treatment groups) of cases. EVT was associated with an increased OR of having a mRS score of 0\u20131 at 3 months after stroke (adjusted OR 7.59 [95% CI 1.28\u201361.60]). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Penumbral tissues were persistent in a substantial proportion of anterior circulation occlusion cases 6\u201312 h after LSN. EVT at 6\u201312 h in a predominantly Asian cohort resulted in better outcomes.<\/jats:p>","DOI":"10.1159\/000489894","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T21:01:32Z","timestamp":1528405292000},"page":"263-269","source":"Crossref","is-referenced-by-count":4,"title":["Tenacity of Collateral Perfusion in Proximal Cerebral Arterial Occlusions 6\u201312 h after Onset"],"prefix":"10.1159","volume":"45","author":[{"given":"Beom\u00a0Joon","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeran","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Gil","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi\u00a0Hwa","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol\u00a0Kyu","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon-Ku","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u00a0Hyoung\u00a0","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew\u00a0M.","family":"Demchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Joon","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000086465.41263.06"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020200"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2503080811"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh162"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004858"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.17.1.38"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e318284056a"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.01655"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007466"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.2.438"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70203-X"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010508"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004870"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018560"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017673"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033579"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2017.00885"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2017.00752"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2017.00178"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489894","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:33:47Z","timestamp":1745426027000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":22,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2018,8,2]]},"published-print":{"date-parts":[[2018,8,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000489894","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.6454877","asserted-by":"subject"}]},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"type":"print","value":"1015-9770"},{"type":"electronic","value":"1421-9786"}],"subject":[],"published":{"date-parts":[[2018]]}}}