{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:36:15Z","timestamp":1780626975975,"version":"3.54.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Epilepsy is a chronic medical disease and is associated with comorbid adverse somatic conditions due to epilepsy itself or its long-term treatment. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; This study evaluated cochlear function in patients with idiopathic epilepsy and treated with carbamazepine (CBZ). &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; Included were 47 patients (mean age = 34.56 \u00b1 7.11 years and duration of illness = 17.84 \u00b1 7.21 years) and 40 healthy subjects. They underwent pure-tone audiometry and transient evoked otoacoustic emission (TEOAE) analyses. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Hearing loss (mainly bilateral mild) was reported in one third of patients. Compared to controls, patients had lower TEOAE amplitudes at 1.0\u20134.0 kHz particularly at high frequencies (3 and 4 kHz). Significant correlations were identified between TEOAE amplitudes with CBZ dose (at 3 kHz: &lt;i&gt;r&lt;\/i&gt; = \u20130.554, &lt;i&gt;p&lt;\/i&gt; = 0.008; at 4 kHz: &lt;i&gt;r&lt;\/i&gt; = \u20130.347, &lt;i&gt;p&lt;\/i&gt; = 0.01), its serum level (at 4 kHz: &lt;i&gt;r&lt;\/i&gt; = \u20130.280, &lt;i&gt;p&lt;\/i&gt; = 0.045) and duration of treatment (at 3 kHz: &lt;i&gt;r&lt;\/i&gt; = \u20130.392, &lt;i&gt;p&lt;\/i&gt; = 0.008;&lt;b&gt;&lt;i&gt;&lt;\/i&gt;&lt;\/b&gt; at 4 kHz: &lt;i&gt;r&lt;\/i&gt; = \u20130.542, &lt;i&gt;p&lt;\/i&gt; = 0.001). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Long-term CBZ treatment may result in cochlear dysfunction and auditory deficits.<\/jats:p>","DOI":"10.1159\/000490232","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T21:02:21Z","timestamp":1532638941000},"page":"63-72","source":"Crossref","is-referenced-by-count":6,"title":["Cochlear Function in Adults with Epilepsy and Treated with Carbamazepine"],"prefix":"10.1159","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1441-3530","authenticated-orcid":false,"given":"Sherifa\u00a0A.","family":"Hamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira\u00a0M.","family":"Oseilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,7,26]]},"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/490232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/490232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:37:19Z","timestamp":1745426239000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000490232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,8,29]]},"published-print":{"date-parts":[[2018,9,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000490232","archive":["Portico"],"relation":{},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"value":"1420-3030","type":"print"},{"value":"1421-9700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}