{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:52:09Z","timestamp":1766181129258,"version":"3.40.5"},"reference-count":43,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Purpose:<\/i><\/b> To determine whether serum chitinase-3-like protein 1 (CHI3L1) and interleukin-6 (IL-6) levels correlate with serous retinal detachment (SRD) in diabetic macular edema (DME) using spectral-domain optical coherence tomography (SD-OCT). <b><i>Methods:<\/i><\/b> In this cross-sectional case-control study, 394 patients (treatment-naive DME patients, <i>n<\/i> = 218; diabetic patients without DME, <i>n<\/i> = 96; nondiabetic controls, <i>n<\/i> = 80) were included in the study. Eyes were classi\ufb01ed according to SD-OCT features of DME: SRD, cystoid macular edema (CMO), and diffuse retinal thickness (DRT). Serum concentrations of CHI3L1 and IL-6 were analyzed using enzyme-linked immunosorbent assay. <b><i>Results:<\/i><\/b> Serum CHI3L1 and IL-6 levels were significantly higher in DME with SRD compared to patients with CMO and DRT (<i>p<\/i> &#x3c; 0.001 for all groups). Multivariate regression analysis showed that CHI3L1 and IL-6 had a stronger influence on the presence of SRD in DME (<i>r<\/i> = 1.162, <i>p<\/i> = 0.026, and <i>r<\/i> = 1.242, <i>p<\/i> = 0.016, respectively). Serum concentration of CHI3L1 was significantly correlated with that of IL-6 (<i>r<\/i> = 0.386, <i>p<\/i> = 0.0015). <b><i>Conclusions:<\/i><\/b> Our data suggest that serum concentrations of CHI3L1 and IL-6 are involved in the process of SRD in DME. CHI3L1 can be investigated further as a new diagnostic biomarker for DME with SRD.<\/jats:p>","DOI":"10.1159\/000490534","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T21:01:24Z","timestamp":1534971684000},"page":"90-97","source":"Crossref","is-referenced-by-count":14,"title":["A Novel Biomarker in Diabetic Macular Edema with Serous Retinal Detachment: Serum Chitinase-3-Like Protein 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