{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:43:33Z","timestamp":1790804613467,"version":"4.1.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; The SYNERGY (Saizen\u00ae for Your New Life and Brighter Tomorrow without Growth Deficiency) study is the first randomised multi-centre, open-label study to assess the short-term efficacy and safety of this recombinant human growth hormone (r-hGH) preparation for prepubertal children with idiopathic short stature in South Korea. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The SYNERGY study (ClinicalTrials.gov NCT01746862) was conducted at 9 centres throughout South Korea between December 2012 and March 2015. The primary endpoint was difference in height velocity from baseline to 6 months in the treatment and control arms. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; 97 children were screened; 90 were randomly assigned: 60 children to 0.067 mg\/kg\/day r-hGH for 12 months (treatment) and 30 children to 6 months of no treatment followed by 0.067 mg\/kg\/day r-hGH for 6 months (control). The 6-month mean height velocity in the treatment group increased from 5.63 cm\/year (SD 1.62) to 10.08 cm\/year (SD 1.92) (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001) and from 4.94 cm\/year (SD 1.91) to 5.92 cm\/year (SD 2.01) (&lt;i&gt;p&lt;\/i&gt; = 0.0938) in the control group (between-group difference 3.47 cm\/year, 95% CI 2.17\u20134.78; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001). Adherence was &amp;#x3e; 90% throughout the study. The safety profile was consistent with that already known for r-hGH. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Treatment with r-hGH in the SYNERGY study demonstrated a statistically significant increase in height velocity at 6 months.<\/jats:p>","DOI":"10.1159\/000491016","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T21:01:32Z","timestamp":1534366892000},"page":"44-53","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Growth Hormone Therapy on Height Velocity in Korean Children with Idiopathic Short Stature: A Phase III Randomised Controlled 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