{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:25:13Z","timestamp":1762917913704,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To investigate the clinical results and prognostic factors of multiple dose methotrexate (Mtx) treatment of ectopic pregnancy patients with high initial serum (human chorionic gonadotropin [hCG]). &lt;b&gt;&lt;i&gt;Design:&lt;\/i&gt;&lt;\/b&gt; Retrospective cohort study. &lt;b&gt;&lt;i&gt;Patients:&lt;\/i&gt;&lt;\/b&gt; Twenty-six ectopic pregnancy patients with serum (\u03b2hCG) &amp;#x3e; 5,000 mIU\/mL who received multiple doses of Mtx (1 mg\/kg) with folinic acid rescue on the alternating days. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Success rate was 88.5%. All failures were tubal ruptures in those who underwent surgery. Median initial hCG values of the success and the failure patients were 8,582 (5,058\u201331,114) and 5,280 (5,042\u201313,563) mIU\/mL respectively (&lt;i&gt;p&lt;\/i&gt; &amp;#x3e; 0.05). Side effects were seen in 18 patients (69.2%, one bone marrow suppression and 17 minor side effects). The number of Mtx injections (7.04 \u00b1 1.71), Mtx dose (71.35 \u00b1 13.16 mg) and follow-up period (42.04 \u00b1 23.77 days) did not differ between groups. Body mass index (BMI), Mtx dose, number of Mtx and change in \u03b2hCG levels between the initials and the levels measured 2 days after the 3rd, 4th, and 5th Mtx injections were found to be highly predictive for tubal rupture. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Multiple-dose Mtx treatment of ectopic pregnancies with high initial hCG is safe and effective. BMI, Mtx dose, number of Mtx injections and the decrement of \u03b2hCG levels were found as highly predictive for the success of the treatment.<\/jats:p>","DOI":"10.1159\/000491083","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T21:01:23Z","timestamp":1533934883000},"page":"56-63","source":"Crossref","is-referenced-by-count":6,"title":["Multidose Methotrexate Treatment of Ectopic Pregnancies with High initial \u03b2-Human Chorionic Gonadotropin: Can Success Be Predicted?"],"prefix":"10.1159","volume":"84","author":[{"given":"Niyazi","family":"Tug","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet\u00a0Akif","family":"Sargin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Yassa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,8,10]]},"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/491083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/491083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:44:58Z","timestamp":1745426698000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000491083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,10]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,23]]},"published-print":{"date-parts":[[2019,1,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000491083","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2018,8,10]]}}}