{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:34:34Z","timestamp":1782218074457,"version":"3.54.5"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>The use of gonadotropin-releasing hormone analogs (GnRHa) for the treatment of central precocious puberty (CPP), especially in girls, has increased rapidly in recent years. In the context of a secular trend towards earlier puberty onset, many girls now treated for CPP are healthy children experiencing puberty onset within the early end of the normal range. Justifications for GnRHa treatment include the preservation of adult height (AH) potential and the alleviation of presumed distress of early maturation and menarche. With a case of a family requesting treatment for an 8-year-old girl in early puberty as a background, studies of the effect of untreated CPP and of GnRHa treatment of CPP on AH are reviewed. In addition, the limited evidence relating CPP to significant psychological distress \u2013 in part due to early menses, and for the amelioration of such distress by GnRHa treatment \u2013 is discussed. Taken together, current information suggests that for girls with mildly early onset of puberty (ages 7\u20139 years), an informed assent discussion with the family should include the consideration of reassurance and observation for many girls who might otherwise receive 2\u20134 years of GnRHa treatment for a poorly defined benefit and at a cost of at least $20\u201330,000 per year.<\/jats:p>","DOI":"10.1159\/000491103","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T21:01:30Z","timestamp":1532638890000},"page":"1-7","source":"Crossref","is-referenced-by-count":43,"title":["Toward More Targeted and Cost-Effective Gonadotropin-Releasing Hormone Analog Treatment in Girls with Central Precocious Puberty"],"prefix":"10.1159","volume":"90","author":[{"given":"Paul\u00a0B.","family":"Kaplowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe\u00a0F.","family":"Backeljauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0B.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198112243052602"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80767-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03370190097031"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.4.505"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3079"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1813F"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000455968"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.4.936"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.1.47"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83200-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/adc.81.4.329"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0321"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1216"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000231994"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1783"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70221-0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2011.005"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.881794"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80489-3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb08602.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000479688"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2016.01053"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.10.020"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2013-0286"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2016.10.011"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000353759"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1410140"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/491103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/491103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:45:12Z","timestamp":1745426712000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000491103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,9,6]]},"published-print":{"date-parts":[[2018,9,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000491103","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}