{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:47:12Z","timestamp":1767988032231,"version":"3.49.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>Melanomas are known as the great mimicker and must be considered in the differential diagnosis of any fine-needle aspirations (FNA). Despite recent advancements in understanding of the mutational landscape of melanomas, there still exists a divide between the genetic and morphologic correlates. A consecutive cohort of 39 FNA of clinically verified metastatic melanomas with concurrent &lt;i&gt;BRAF&lt;\/i&gt; V600 assessment were selected [positive (&lt;i&gt;n&lt;\/i&gt; = 18) and wild-type (&lt;i&gt;n&lt;\/i&gt; = 21)]. The melanoma cytology specimens were evaluated blinded to the &lt;i&gt;BRAF&lt;\/i&gt; mutation status in a dichotomized fashion for the presence of 8 selected morphologic classifiers. When comparing the&lt;i&gt; BRAF&lt;\/i&gt;-mutated vs. &lt;i&gt;BRAF&lt;\/i&gt;-wild type cohorts, the percentage of cases were, respectively: macronucleoli (56 and 52%), intranuclear inclusions (50 and 33%), pigment (44 and 24%), binucleation\/multinucleation (78 and 57%), nuclear pleomorphism (72 and 67%), cytoplasmic vacuolization (22 and 29%), spindle cell morphology (61 and 29%), and necrosis (11 and 10%). The average age of the &lt;i&gt;BRAF&lt;\/i&gt;-mutated cohort was 52.2 years, compared to the &lt;i&gt;BRAF&lt;\/i&gt; wild-type cohort at 65.2 years. The prevalence of sex ratio and the location of the primary melanoma were matched between cohorts. Spindle cell morphology was more correlated with &lt;i&gt;BRAF&lt;\/i&gt; V600-mutated melanomas. Clinicians utilized the &lt;i&gt;BRAF&lt;\/i&gt; status to alter clinical decisions with use of BRAF inhibitors.<\/jats:p>","DOI":"10.1159\/000491814","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T22:01:30Z","timestamp":1541455290000},"page":"10-16","source":"Crossref","is-referenced-by-count":6,"title":["&lt;b&gt;&lt;i&gt;BRAF&lt;\/i&gt;&lt;\/b&gt; V600 Mutational Status in Melanoma Correlates with Cytologic Features in Fine-Needle Aspirate Specimens"],"prefix":"10.1159","volume":"63","author":[{"given":"Paul\u00a0J.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashna","family":"Madan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,11,5]]},"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/491814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/491814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:49:37Z","timestamp":1745426977000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000491814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,5]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,2,20]]},"published-print":{"date-parts":[[2019,2,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000491814","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,5]]}}}