{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:28:49Z","timestamp":1745468929429,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Arteriovenous fistulae impair the distal circulation, but their effects at the microcirculatory level are not well understood. This study presents the carotid-jugular fistula (CJF) as a model to evaluate fistula-related microcirculatory and systemic changes. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; Female Wistar rats were anesthetized and divided into a fistula group (FG, &lt;i&gt;n&lt;\/i&gt; = 10) and a sham group (SG, &lt;i&gt;n&lt;\/i&gt; = 6). End-to-end anastomosis was performed between the right carotid artery and the jugular vein in the FG. The hemodynamic status was followed for 6 weeks. On the sixth postoperative week, liver and kidney microcirculation was measured using laser Doppler; then microcirculatory changes were assessed after occlusion of the carotid artery. At the end of the experiment, histological samples were taken and the weights of the organs were measured. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The heart rate and systolic blood pressure decreased significantly due to the CJF. Laser Doppler showed a reduction in liver blood flow units (BFU) in the FG in comparison with the SG (&lt;i&gt;p&lt;\/i&gt; = 0.01), and they increased (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01) after occlusion of the fistula. Kidney BFU showed slight changes only. The comparative morphological study revealed significant increases in heart weight (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) and left ventricular hypertrophy (&lt;i&gt;p&lt;\/i&gt; = 0.008) in the FG. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Beside hemodynamic and morphologic changes, a CJF causes a deterioration in the microcirculation of the liver rather than of the kidney, but occlusion of the CJF immediately reverses these changes.<\/jats:p>","DOI":"10.1159\/000491930","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T21:01:24Z","timestamp":1536613284000},"page":"268-277","source":"Crossref","is-referenced-by-count":6,"title":["Carotid-Jugular Fistula Model to Study Systemic Effects and Fistula-Related Microcirculatory Changes"],"prefix":"10.1159","volume":"55","author":[{"given":"Souleiman","family":"Ghanem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bence","family":"Tanczos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Deak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Bidiga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Nemeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2015.07.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00311.2011"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00433.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090649"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.01.025"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-012-9305-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2451"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2174\/1874303X01407010014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91071-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3791\/50472"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-956236"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh124"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00248.2002"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.4.627"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.12.4.519"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-8181-5_76"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146212"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.1.52"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00219-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp033"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20784"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.5.H1500"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2009.01.006"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087531"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1979.236.5.H698"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3109\/03091909009009955"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.6.2907"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.2.H674"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/491930","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/491930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:50:27Z","timestamp":1745427027000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000491930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,11,9]]},"published-print":{"date-parts":[[2018,11,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000491930","archive":["Portico"],"relation":{},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"type":"print","value":"1018-1172"},{"type":"electronic","value":"1423-0135"}],"subject":[],"published":{"date-parts":[[2018]]}}}