{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:29:32Z","timestamp":1787790572649,"version":"build-2784847793"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Minimizing initial neonatal blood draws and their associated pain is important. The placenta has ample fetal blood that is otherwise discarded; obtaining admission laboratory evaluations from fetal umbilical venous blood (FUVB) may provide a suitable alternative. <b><i>Objective:<\/i><\/b> We hypothesized that obtaining an aerobic bacterial blood culture (BCX) and a complete blood count with manual differential (CBC\/diff) from FUVB is feasible and yields results comparable to those obtained directly from the neonate. <b><i>Study Design:<\/i><\/b> BCX and CBC\/diff were attempted on paired samples from FUVB (in the delivery room) and neonatal blood (shortly after NICU admission) of 110 patients. The paired <i>t<\/i> test, Pearson\u2019s correlation coefficient (<i>R<\/i>), and multivariable linear regression were used for data analysis. <b><i>Results:<\/i><\/b> Positive BCXs were found in 9 of 108 FUVB samples compared to 1 of 91 neonatal samples. Three out of 9 FUVB cultures were true pathogens, including 2 <i>Escherichia coli<\/i> and 1 viridans group streptococcus, all with negative corresponding paired neonatal cultures. There was 1 positive neonatal BCX, <i>E. coli<\/i>, with a negative paired FUVB culture. Neonatal hemoglobin (Hb), platelets (PLT), and white blood cells (WBC) all significantly (<i>p<\/i> &#x3c; 0.0001) correlated with the paired FUVB samples (<i>R<\/i> = 0.50, 0.49, and 0.84, respectively). Hb, PLT, and WBC values were clinically comparable but statistically higher in neonatal blood (the differences were 2.3 g\/dL, 30,000 cells\/\u03bcL, and 2,800 cells\/\u03bcL, respectively; <i>p<\/i> &#x3c; 0.007 for all comparisons). <b><i>Conclusions:<\/i><\/b> FUVB is suitable for obtaining CBC\/diff. FUVB is an appropriate second source for BCX as it yields additional true pathogens. Our findings may support the presence of \u201cculture-negative sepsis\u201d in some neonates.<\/jats:p>","DOI":"10.1159\/000491993","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T21:02:38Z","timestamp":1539118958000},"page":"49-58","source":"Crossref","is-referenced-by-count":24,"title":["Can Fetal Umbilical Venous Blood Be a Reliable Source for Admission Complete Blood Count and Culture in NICU Patients?"],"prefix":"10.1159","volume":"115","author":[{"given":"Rocky","family":"Greer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azif","family":"Safarulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Koeppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayez\u00a0M.","family":"Bany-Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-0434"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1773"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1053862"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2217"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/fn.87.1.F25"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-4-199308150-00003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0440"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4271"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.069328"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02827.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2015.04.017"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.127"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.171"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000083946"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/0009922811431882"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.825597"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.60"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2008.10.010"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/bmjquality.u215456.w4946"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.30.3.175"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.1.74"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2003.00484.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.10.231"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.1906"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000041056"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1565923"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2015.04.012"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/491993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/491993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:50:47Z","timestamp":1745427047000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000491993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,9]]},"published-print":{"date-parts":[[2019,1,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000491993","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,9]]}}}