{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:08:45Z","timestamp":1793261325993,"version":"4.5.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Hydrogen-oxygen mixture (H<sub>2<\/sub>-O<sub>2<\/sub>) may reduce airway resistance in patients with acute severe tracheal stenosis, yet data supporting the clinical use of H<sub>2<\/sub>-O<sub>2<\/sub> are insufficient. <b><i>Objectives:<\/i><\/b> To evaluate the efficacy and safety of breathing H<sub>2<\/sub>-O<sub>2<\/sub> in acute severe tracheal stenosis. <b><i>Methods:<\/i><\/b> Thirty-five consecutive patients with severe acute tracheal stenosis were recruited in this prospective self-control study. Air, H<sub>2<\/sub>-O<sub>2<\/sub> and O<sub>2<\/sub> inhalation was given in 4 consecutive breathing steps: air for 15 min, H<sub>2<\/sub>-O<sub>2<\/sub> (6 L per min, H<sub>2<\/sub>:O<sub>2<\/sub> = 2: 1) for 15 min, oxygen (3 L per min) for 15 min, and H<sub>2<\/sub>-O<sub>2<\/sub> for 120 min. The primary endpoint was inspiratory effort as assessed by diaphragm electromyography (EMGdi); the secondary endpoints were transdiaphragmatic pressure (Pdi), Borg score, vital signs, and impulse oscillometry (IOS). The concentration of H<sub>2<\/sub> in the ambient environment was obtained with 12 monitors. Adverse reactions during the inhalation were recorded. <b><i>Results:<\/i><\/b> The mean reduction in the EMGdi under H<sub>2<\/sub>-O<sub>2<\/sub> was 10.53 \u00b1 6.83%. The EMGdi significantly decreased during 2 H<sub>2<\/sub>-O<sub>2<\/sub> inhalation steps (Steps 2 and 4) compared with air (Step 1) and O<sub>2<\/sub> (Step 3) (52.95 \u00b1 15.00 vs. 42.46 \u00b1 13.90 vs. 53.20 \u00b1 14.74 vs. 42.50 \u00b1 14.12% for Steps 1 through 4, <i>p<\/i> &#x3c; 0.05). The mean reduction in the Pdi under H<sub>2<\/sub>-O<sub>2<\/sub> was 4.77 \u00b1 3.51 cmH<sub>2<\/sub>O. Breathing H<sub>2<\/sub>-O<sub>2<\/sub> significantly improved the Borg score and resistance parameters of IOS but not vital signs. No adverse reactions occurred. H<sub>2<\/sub> was undetectable in the environment throughout the procedure. <b><i>Conclusions:<\/i><\/b> Breathing H<sub>2<\/sub>-O<sub>2<\/sub> may reduce the inspiratory effort in patients with acute severe tracheal stenosis and can be used for this purpose safely.<\/jats:p>","DOI":"10.1159\/000492031","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T21:01:20Z","timestamp":1537304480000},"page":"42-51","source":"Crossref","is-referenced-by-count":42,"title":["Breathing Hydrogen-Oxygen Mixture Decreases Inspiratory Effort in Patients with Tracheal Stenosis"],"prefix":"10.1159","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-2075","authenticated-orcid":false,"given":"Zi-Qing","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu-Quan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Li","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Qian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,9,18]]},"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:51:11Z","timestamp":1745427071000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000492031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,18]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12,12]]},"published-print":{"date-parts":[[2018,12,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000492031","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,18]]}}}