{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T21:09:59Z","timestamp":1775941799164,"version":"3.50.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of the study was to evaluate the efficacy, tolerability, and safety of once-a day trazodone tablets (Trittico Prolong\u00ae 300 mg) in patients with moderate to severe depression in routine clinical practice. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Men and women \u226518 years old with Montgomery-\u00c5sberg Depression\u00a0Rating Scale (MADRS) scores &amp;#x3e; 21 and Clinical Global Impression \u2013 Severity (CGI\/S) \u22654 were included in this post-authorization, non-interventional, observational prospective safety study, conducted in 8 psychiatric centers in the Czech \u00adRepublic. The acute treatment phase lasted 5 weeks: 1 week of\u00a0titration and 4 weeks of full-dose treatment. Patients had\u00a0follow-up visits 9 and 21 weeks after commencing \u00adtreatment. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Overall, 85 patients were enrolled in the\u00a0study, of which 80 completed the acute treatment of 5\u00a0weeks. There were significant decreases in the overall MADRS score from the baseline mean value of 27.4\u201321.2 at week 1 (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001), and a further decrease to 7.9 at week 5\u00a0(&lt;i&gt;p\u00a0&lt;\/i&gt;&amp;#x3c; 0.001). The severity of depression according to CGI\/S gradually declined. Most patients reported improvement after 6 days of trazodone treatment. The most frequent adverse drug reactions (ADRs) reported were somnolence and fatigue. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Trazodone, in the new extended-release formulation, had very good effects in clinical practice, both in previously untreated depressive episodes and in episodes not responsive to previous antidepressive therapy.<\/jats:p>","DOI":"10.1159\/000492079","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T21:01:28Z","timestamp":1533934888000},"page":"206-212","source":"Crossref","is-referenced-by-count":16,"title":["Once-a-Day Trazodone in the Treatment of Depression in Routine Clinical Practice"],"prefix":"10.1159","volume":"102","author":[{"given":"Eva","family":"\u010ce\u0161kov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"\u0160edov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Kellnerov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Starobov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,8,10]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:51:41Z","timestamp":1745427101000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000492079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2018,9,13]]},"published-print":{"date-parts":[[2018,9,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000492079","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}