{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:26:15Z","timestamp":1789910775873,"version":"4.0.1"},"reference-count":50,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from &lt;i&gt;Tamarindus indica&lt;\/i&gt; L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese &lt;i&gt;Wistar&lt;\/i&gt; rats. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina\u00ae) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Lean animals were fed the standard diet for the 10 days. Food intake, zoometric measurements, plasma CCK, plasma leptin, relative mRNA expression of intestinal CCK-related genes, and expression of the &lt;i&gt;ob&lt;\/i&gt; gene in subcutaneous adipose tissue were assessed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; TTI decreased food intake but did not increase plasma CCK in obese animals. On the other hand, TTI treatment decreased &lt;i&gt;CCK-1R&lt;\/i&gt; gene expression in obese animals compared with the obese group with no treatment (&lt;i&gt;p&lt;\/i&gt; = 0.027). Obese animals treated with TTI presented lower plasma leptin than the non-treated obese animals. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; We suggest that TTI by decreasing plasma leptin may improve CCK action, regardless of its increase in plasma from obese rats, since food intake was lowest.<\/jats:p>","DOI":"10.1159\/000492733","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T22:01:27Z","timestamp":1544565687000},"page":"440-453","source":"Crossref","is-referenced-by-count":25,"title":["Satietogenic Protein from Tamarind Seeds Decreases Food Intake, Leptin Plasma and &lt;b&gt;&lt;i&gt;CCK-1r&lt;\/i&gt;&lt;\/b&gt; Gene Expression in Obese Wistar 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