{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:08:13Z","timestamp":1788343693048,"version":"build-2803163510"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; The objective of this study was to evaluate the effects of intratunical injection of platelet rich plasma (PRP) for the treatment of Peyronie\u2019s disease (PD) in a rat model. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; Twenty male Sprague-Dawley rats (300\u2013350 g) were randomly divided into 4 groups: sham, PD, PD + PRP, and PRP. The PD + PRP groups received intratunical injections with 0.1 mL PRP on day 15 (treatment) or day 0 (PRP effect). Forty-five days following transforming growth factor-beta 1 injection, rats underwent pathological examination. Tissues were evaluated histologically for fibrosis grade (Haematoxylin &amp;amp; Eosin staining), collagen\/smooth muscle ratio (Masson Trichrome staining) and type III\/type I collagen ratio (Picro-sirius red staining). Statistical analysis was performed by Kruskal-Wallis and chi-square followed by the Mann-Whitney U test for post hoc comparisons. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Significant changes were found in all 3 groups compared to the sham group (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001 for fibrosis, &lt;i&gt;p&lt;\/i&gt; = 0.001 for collagen\/smooth muscle ratio and &lt;i&gt;p&lt;\/i&gt; = 0.003 for type III\/type I collagen ratio). The values in the PRP group and the findings in the PD group are similar (&lt;i&gt;p&lt;\/i&gt; = 0.122 for fibrosis, &lt;i&gt;p&lt;\/i&gt; = 0.221 for collagen\/smooth muscle ratio and &lt;i&gt;p&lt;\/i&gt; = 1.0 for type III\/type I collagen ratio). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This is the first study of PRP on PD. As a result of pathological examinations, PRP shows PD-like effects in rats. PRP may be a cheap, easily accessible, and an effective disease model for PD treatment research.<\/jats:p>","DOI":"10.1159\/000492755","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T21:01:20Z","timestamp":1539378080000},"page":"218-223","source":"Crossref","is-referenced-by-count":25,"title":["The Effect of Platelet-Rich Plasma on Peyronie\u2019s Disease in Rat Model"],"prefix":"10.1159","volume":"102","author":[{"given":"Mehmet\u00a0Gokhan\u00a0","family":"Culha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Erkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugce","family":"Cay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u011fur","family":"Y\u00fcceta\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,10,12]]},"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:45:37Z","timestamp":1745426737000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000492755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,12]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,3,21]]},"published-print":{"date-parts":[[2019,3,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000492755","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,12]]}}}