{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:46:22Z","timestamp":1790059582193,"version":"4.0.1"},"reference-count":53,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer\u2019s disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In this cross-sectional study, 49 patients with a diagnosis of AD (&lt;i&gt;n&lt;\/i&gt; = 17), FTD (&lt;i&gt;n&lt;\/i&gt; = 19), or DLB (&lt;i&gt;n&lt;\/i&gt; = 13) were included and underwent cognitive testing, clinical motor evaluation, and quantitative motor tests: pronation\/supination hand tapping, grasping and lifting, and finger and foot tapping. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Our results revealed significantly higher Q-Motor values in pronation\/supination and in grip lift force assessment in AD, FTD, and DLB compared to healthy controls (HC). Q-Motor values detected significant differences between AD and HC, while clinical ratings did not. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia.<\/jats:p>","DOI":"10.1159\/000492860","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T21:01:29Z","timestamp":1537995689000},"page":"168-179","source":"Crossref","is-referenced-by-count":18,"title":["Quantitative Measurements of Motor Function in Alzheimer\u2019s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study"],"prefix":"10.1159","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-2919","authenticated-orcid":false,"given":"Frederikke","family":"Jeppesen\u00a0Kragh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bruun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esben","family":"Budtz-J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena\u00a0Elisabeth","family":"Hjermind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Reilmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen\u00a0Erik","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen\u00a0Gregers","family":"Hasselbalch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7886-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9616-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31826f040d"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.3.243"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-6365-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199601020-00008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000138440.39918.0C"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000162054.15428.E9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.6.1284"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00461-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.05.049"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01773.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00462-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000375363"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302577"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/01.JGP.0000216177.08010.f4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/gps.443"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440524"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801893-4.00018-3"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7348"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70088-7"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70263-0"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123914"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-015-1383-7"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6639-7"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-015-0517-8"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(03)00092-7"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2013.00446.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.11.1803"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000434309.85312.19"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.08.005"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1997.tb00299.x"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/11.3.260"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.920"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23816"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182020123"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23300"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26174"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70170-X"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.10.005"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8841-8"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1159\/000305095"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-29821-4"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(92)90139-C"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.26.041002.131032"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492860","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:46:33Z","timestamp":1745426793000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000492860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":53,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2018,11,9]]},"published-print":{"date-parts":[[2018,11,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000492860","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.7133234","asserted-by":"subject"}]},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}