{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:53:36Z","timestamp":1773431616430,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to evaluate risk factors for the development of retinal pigment epithelium (RPE) atrophy in patients with neovascular age-related macular degeneration (nAMD). &lt;b&gt;&lt;i&gt;Procedures:&lt;\/i&gt;&lt;\/b&gt; This post hoc analysis of the prospective RESPONSE study includes 52 therapy-naive nAMD patients without baseline RPE atrophy, who were treated with \u22659 anti-vascular endothelial growth factor (VEGF) injections for \u22653 years. RPE atrophy was assessed via multimodal imaging. Baseline aqueous VEGF and serum complement levels (C3d\/C3) were measured. Risk factors for atrophy development were evaluated via logistic regression analysis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Atrophy onset was significantly associated with the duration of nAMD (mean 5.34 years; odds ratio = 1.83, &lt;i&gt;p&lt;\/i&gt; = 0.012). Anti-VEGF injection number, age, C3d\/C3 ratio, baseline intraocular VEGF, or delay to the first treatment had no influence on RPE atrophy. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The duration of treatment-requiring nAMD was identified as primary risk factor for the onset of concomitant RPE atrophy after commencing therapy. Targeting concomitant atrophy in nAMD patients might improve the long-term prognosis of the disease.<\/jats:p>","DOI":"10.1159\/000492924","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T21:01:20Z","timestamp":1539205280000},"page":"154-160","source":"Crossref","is-referenced-by-count":10,"title":["Onset of Retinal Pigment Epithelium Atrophy Subsequent to Anti-VEGF Therapy in Patients with Neovascular Age-Related Macular Degeneration"],"prefix":"10.1159","volume":"241","author":[{"given":"Vasilena","family":"Sitnilska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-3786","authenticated-orcid":false,"given":"Lebriz","family":"Altay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-4957","authenticated-orcid":false,"given":"Philip","family":"Enders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp\u00a0S.","family":"Muether","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"Fauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.036"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1568-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3448"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054481"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.2480"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001059"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1988.106"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182657fff"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000374"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.10.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.09.012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61501-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00973.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2008.05.002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61231-X"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2011.10.001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000188"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.07.041"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16989"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.056"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.12.002"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.37"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-2038-0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.06.034"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492924","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:46:57Z","timestamp":1745426817000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000492924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,10]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,28]]},"published-print":{"date-parts":[[2019,4,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000492924","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,10]]}}}