{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:06:04Z","timestamp":1771549564358,"version":"3.50.1"},"reference-count":26,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Evidence of cortical beta-amyloid (A\u03b2) load, assessed by A\u03b2 positron emission tomography (A\u03b2-PET), is an established in vivo biomarker of Alzheimer\u2019s disease (AD)-related pathophysiology. Qualitative assessment of A\u03b2-PET provides binary information; meanwhile semiquantitative approaches require a parcellation of PET image either manually or by placement of atlas-based volumes of interest. We supposed that a whole-brain approach with voxel-by-voxel standardized uptake value ratio (SUVr) parametric images may better elucidate the spatial trajectories of A\u03b2 burden along the continuum&lt;i&gt;&lt;\/i&gt; of AD. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We recruited 32 subjects with a diagnosis of probable AD dementia (ADD, &lt;i&gt;n&lt;\/i&gt; = 20) and mild cognitive impairment due to AD (MCI-AD, &lt;i&gt;n&lt;\/i&gt; = 12) according to the NIA-AA 2011 criteria. We also enrolled a control group of 6 cognitively healthy individuals (HCs) with preserved cognitive functions and negative A\u03b2-PET scan. The PET images were spatially normalized using the AV45 PET template in the MNI brain space. Subsequently, parametric SUVr images were calculated using the whole cerebellum as a reference region. A voxel-wise analysis of covariance was used to compare (between groups) the \u0391\u03b2 distribution pattern considering age as a nuisance covariate. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Both ADD and MCI-AD subjects showed a widespread increase in radiotracer uptake when compared with HC participants (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001, uncorrected). After applying a multiple comparison correction (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05, corrected), a relative large cluster of increased [&lt;sup&gt;18&lt;\/sup&gt;F]-flor\u00adbetapir uptake was observed in the precuneus in the ADD and MCI-AD groups compared to HCs. Voxel-wise regression analysis showed a significant positive linear association between the voxel-wise SUVr values and the disease duration. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The voxel-wise semiquantitative analysis shows that the precuneus is a region with higher vulnerability to A\u03b2 depositions when compared to other cortical regions in both MCI-AD and ADD subjects. We think that the precuneus is a promising PET-based outcome measure for clinical trials of drugs targeting brain A\u03b2. We found a positive association between the overall A\u03b2-PET SUVr and the disease duration suggesting that the region-specific slow saturation of A\u03b2 deposition continuously takes place as the disease progresses.<\/jats:p>","DOI":"10.1159\/000492945","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T06:50:59Z","timestamp":1551336659000},"page":"302-309","source":"Crossref","is-referenced-by-count":18,"title":["The Precuneus \u2013 A Witness for Excessive A\u03b2 Gathering in Alzheimer\u2019s Disease Pathology"],"prefix":"10.1159","volume":"18","author":[{"given":"Gayane","family":"Aghakhanyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Vergallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Gennaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mazzarri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Guidoccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Radicchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Ceravolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Tognoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubaldo","family":"Bonuccelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duccio","family":"Volterrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.09.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002923"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.241"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3842-c1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.01.002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4281"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.09.004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.153494"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0326-z"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp062"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.05.016"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182840bbe"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-007-0269-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5479597"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/583931"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000143"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3263-16.2017"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01150-x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.09.018"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.2216"}],"container-title":["Neurodegenerative 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