{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:43:57Z","timestamp":1781689437862,"version":"3.54.5"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Purpose:<\/i><\/b> We aimed to evaluate the interaction between the overall severity of chronic rhinosinusitis (CRS) before treatment and subjective improvement following surgical or medical treatment. <b><i>Procedures:<\/i><\/b> A group of 97 patients with CRS completed the visual analog scale (VAS) symptom score and the Sino-Nasal Outcome Test 22 (SNOT-22) questionnaire in the moment of their sinus computerized tomography (CT) scan. Data were analyzed via a 2-step cluster analysis based on gender, polyp presence, CT scan, and VAS scores for symptoms. <b><i>Results:<\/i><\/b> There were 3 clusters: the first cluster comprised 37 female patients with CRS without nasal polyps (CRSsNP), the second cluster comprised 30 patients with CRS and NP (CRSwNP; 15 males and 15 females); and third cluster had 30 male patients with CRS without NP (CRSsNP). Different symptom patterns between clusters were identified. After adjustment for polyp presence, gender, eosinophilia (<i>p<\/i> = 0.021), and the SNOT-22 score (<i>p<\/i> = 0.005) were found to be better outcome predictors than the CT score (<i>p<\/i> = 0.26). <b><i>Conclusion:<\/i><\/b> Long-term patient satisfaction is significantly associated with the subjective symptom severity prior to treatment, i.e., postnasal drip and overall disease severity (SNOT-22 score), but not with the objective severity of the disease (CT score and inflammation).<\/jats:p>","DOI":"10.1159\/000492966","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T22:01:55Z","timestamp":1542751315000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["Cluster Analysis of Chronic Rhinosinusitis Suggests Gender-Based Differences"],"prefix":"10.1159","volume":"81","author":[{"given":"Lana","family":"Jurlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomislav","family":"Greguri\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomislav","family":"Baudoin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko\u00a0Velimir","family":"Grgi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Pa\u017eanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andro","family":"Ko\u0161ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenis","family":"Scadding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livije","family":"Kalogjera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino50E2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4140"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4274"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.06.033"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21408"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25318"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.11.019"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000192284.22703.04"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2014.35.3774"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2230-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/all.12040"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20653"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(97)70001-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02693.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3519-7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0175-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2012.02527.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23671"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006991.pub2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.002"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/492966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:47:30Z","timestamp":1745426850000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000492966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,20]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,4,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000492966","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,20]]}}}