{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:53:21Z","timestamp":1782276801579,"version":"3.54.5"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> The analysis of insulin-like growth factor I (IGF-I) is an important tool for pediatricians in the diagnosis and treatment of growth hormone deficiency in children. However, significant differences exist in IGF-I assays and normative datasets, which can have important clinical consequences. <b><i>Methods:<\/i><\/b> IGF-I analyses were performed using the IDS-iSYS platform on 1,897 samples from pediatric patients (0.5\u201318 years old). <i>Z<\/i>-scores were calculated based on normative IGF-I data from Bidlingmaier et al. (SD-BM) [J Clin Endocrinol Metab. 2014 May; 99(5): 1712\u201321] and normative IGF-I data from the IGF-I harmonization program in the Netherlands (SD-NL). The differences in <i>Z<\/i>-scores were analyzed at relevant clinical decision points (\u20132 SD, +2 SD). These normative datasets were also compared to normative data reported by Elmlinger et al. [Clin Chem Lab Med. 2004; 42(6): 654\u201364]. <b><i>Results:<\/i><\/b> The difference in <i>Z<\/i>-score between SD-BM and SD-NL was highest in males between 0 and 3 years old, exceeding 2 SD. Clinically relevant discordance between both <i>Z<\/i>-scores at \u20132 and +2 SD was found in 12.7% of all samples. The IGF-I levels at \u20132 and +2 SD reported in the normative dataset of Elmlinger et al. were up to 100% higher than the IGF-I levels reported by Bidlingmaier et al. or the Dutch harmonization program. <b><i>Conclusion:<\/i><\/b> Pediatricians and laboratory specialists should be aware of relevant differences that can exist between IGF-I assays and normative data. Well-defined pediatric reference ranges for the IDS-iSYS platform are highly desirable.<\/jats:p>","DOI":"10.1159\/000493133","type":"journal-article","created":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T21:01:37Z","timestamp":1538686897000},"page":"181-189","source":"Crossref","is-referenced-by-count":7,"title":["Impact of the Choice of IGF-I Assay and Normative Dataset on the Diagnosis and Treatment of Growth Hormone Deficiency in Children"],"prefix":"10.1159","volume":"90","author":[{"given":"Maarten\u00a0A.C.","family":"Broeren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes\u00a0G.","family":"Krabbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne\u00a0S.","family":"Boesten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita\u00a0C.S.","family":"Hokken-Koelega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda\u00a0B.","family":"de\u00a0Rijke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0024"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.67"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2700"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0179"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000452150"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186296"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0509"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32834ec952"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1377"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.150631"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2009.09.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1257"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13491"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.205070"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2004.112"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3059"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2558"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.01.008"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111005"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1822"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.164012"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.12.015"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.201"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.234799"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000486035"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.208538"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/493133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/493133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:48:37Z","timestamp":1745426917000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000493133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,11,7]]},"published-print":{"date-parts":[[2018,11,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000493133","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}