{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:22:53Z","timestamp":1773951773776,"version":"3.50.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an accurate procedure to sample mediastinal tissue. Rapid on-site cytologic evaluation (ROSE) has been advocated to improve the performance of this procedure, but its benefit remains controversial. Our objective is to assess the utility of ROSE for EBUS-TBNA diagnostic accuracy among unselected patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We prospectively collected data from all consecutive EBUS-TBNA procedures performed between 2008 and 2014. ROSE was introduced since 2011 in our daily practice. The accuracy of EBUS-TBNA with and without ROSE was compared in a univariate and multivariate model accounting for confounding factors. The impact of ROSE was then analyzed according to the etiology and size of the lesions. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among 348 EBUS-TBNA procedures analyzed, 213 were performed with ROSE. The overall accuracy tended to be better with ROSE than without (90.6 vs. 84.4%; &lt;i&gt;p&lt;\/i&gt; = 0.082). After adjustment in a multivariate model, the benefit of ROSE still did not reach statistical significance (adjusted odds ratio 1.86; 95% confidence interval 0.79\u20134.41). Similar results were obtained in subgroups of patients with malignant disease or sarcoidosis. The size of the lesion did not influence the impact of ROSE on accuracy. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; ROSE was associated with a moderate increase in the accuracy of EBUS-TBNA, but the difference was not statistically significant. The same effect of ROSE was observed in malignant and nonmalignant lesions and this effect was not influenced by the lesion\u2019s size.<\/jats:p>","DOI":"10.1159\/000493334","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T21:01:56Z","timestamp":1537563716000},"page":"380-385","source":"Crossref","is-referenced-by-count":15,"title":["Utility of Rapid On-Site Cytologic Evaluation during Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Malignant and Nonmalignant Disease"],"prefix":"10.1159","volume":"62","author":[{"given":"Pietro","family":"Gianella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola\u00a0M.","family":"Soccal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Plojoux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Fr\u00e9sard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Pache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Perneger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9goire","family":"Gex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.047829"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.07.023"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00097908"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.11.043"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.1.59"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.4.1186"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2106153"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000084050"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.869"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000084041"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1521"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0b013e31821707ee"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000346998"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.90081"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.09.074"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.11.038"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000346987"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0583"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000368857"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.04.003"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.9046"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1309\/BLLQF8KDHWW6MJNQ"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPEGZMJKC42VUP"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00128312"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/493334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/493334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:50:34Z","timestamp":1745427034000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000493334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":24,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2018,12,4]]},"published-print":{"date-parts":[[2018,12,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000493334","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.7116992","asserted-by":"subject"}]},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}