{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:07:50Z","timestamp":1768259270905,"version":"3.49.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b><i><\/i> Animal models suggest that neuroprotective effects of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. <b><i>Objectives:<\/i><\/b> To assess the outcome of infants with perinatal asphyxia, neonatal encephalopathy, and TH in the presence of early-onset sepsis. <b><i>Methods:<\/i><\/b> In a retrospective cohort of 1,084 infants with perinatal asphyxia and TH, the outcome of 42 infants (gestational age 36.1\u201342.6 weeks and birth weight 2,280\u20135,240 g) with proven sepsis (<i>n<\/i> = 14) and probable sepsis (<i>n<\/i> = 28) was analyzed. Death, cerebral palsy, or a delayed development at 2 years was considered an adverse outcome. <b><i>Results:<\/i><\/b> Sepsis was caused mostly by group B streptococci (<i>n<\/i> = 17), other Gram-positive bacteria (<i>n<\/i> = 5), and <i>Candida albicans<\/i> (<i>n<\/i> = 1). Of the 42 infants, 9 (21.4%) died, and 5 (11.9%) showed impairments on follow-up. The outcome is comparable to the previously reported outcome of infants with TH without early-onset sepsis. <b><i>Conclusion:<\/i><\/b> A good outcome was reported in the majority of infants with perinatal asphyxia, TH, and early-onset sepsis. Cooling should not be withheld from these infants.<\/jats:p>","DOI":"10.1159\/000493358","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T22:01:26Z","timestamp":1542060086000},"page":"127-133","source":"Crossref","is-referenced-by-count":44,"title":["Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset 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