{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:28:50Z","timestamp":1792146530733,"version":"4.4.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Transbronchial cryobiopsy (cTBB) may offer an alternative to surgical lung biopsy (SLB) for histopathological diagnosis of interstitial lung diseases (ILDs). However, real-life experience is limited, although case series are increasingly reported. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; We aimed to evaluate the value of cTBB performed under real-life conditions in a tertiary care center for ILDs. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Data on all patients undergoing a cTBB for evaluation of suspected ILD between October 2015 and January 2017 were included in this retrospective case series. Procedure details, complication rates, histopathological results, and diagnostic consensus reached by a multidisciplinary team (MDT) discussion were collated and evaluated. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 109 patients (mean age 64 years, range 19\u201385; 66% male, 38% never smokers) referred to our center with features suggestive of ILD underwent cTBB. The mean FVC% predicted was 77% (range 41\u2013131), with a mean DLCO of 51% (range 20\u201386), and a 6-min walking test (6MWT) of 402 m (range 100\u2013642). On average, 4 samples were taken from each patient (range 1\u20138), with a mean biopsy diameter of 5 mm (range 2\u201312). Complications included pneumothorax (11.9%), all treated with chest drain. Moderate bleeding occurred in 28.4% (all resolved without active measures). No acute disease exacerbations and no deaths occurred. A histopathological pattern diagnosis was possible in 80 cases (73.4%), and 26.6% of cases were considered nonspecific. An MDT consensus diagnosis was reached in 83.5% of cases. Subsequent SLB was proposed in 13 cases and performed in 8 cases. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In the real-world setting, cTBB has a meaningful diagnostic value in the context of a MDT approach and may enable histopathological assessment even in patients with more advanced disease unsuitable for SLB.<\/jats:p>","DOI":"10.1159\/000493428","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T22:02:38Z","timestamp":1544824958000},"page":"348-354","source":"Crossref","is-referenced-by-count":39,"title":["Transbronchial Cryobiopsies for Diagnosing Interstitial Lung Disease: Real-Life Experience from a Tertiary Referral Center for Interstitial Lung Disease"],"prefix":"10.1159","volume":"97","author":[{"given":"Julia","family":"W\u00e4lscher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gro\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Eberhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus\u00a0Peter","family":"Heussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Eichinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Warth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Lasitschka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-2506","authenticated-orcid":false,"given":"Felix\u00a0J.F.","family":"Herth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kreuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.16-6-s71"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12694"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.10.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000444089"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000484055"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.70.5.584"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000203987"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2290"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078674"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086716"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.9.2103074"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000381921"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12296"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000439313"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.11.020"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-43"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.rppnen.2017.07.001"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.3.734"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203618"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/493428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/493428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:51:46Z","timestamp":1745427106000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000493428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,14]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,24]]},"published-print":{"date-parts":[[2019,4,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000493428","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.7466708","asserted-by":"subject"}]},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,14]]}}}