{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:06:45Z","timestamp":1785766005682,"version":"3.56.0"},"reference-count":35,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> To report changes in body composition and biochemical parameters in patients with type 1 diabetes mellitus (T1D) after switching from multiple daily injection (MDI) to continuous subcutaneous insulin infusion (CSII). <b><i>Methods:<\/i><\/b> 31 patients switched over from MDI to CSII. Body composition, biochemical parameters, glycaemic variability (GV) and level of physical activity were evaluated before and 6 months on CSII. <b><i>Results:<\/i><\/b> In both sexes, we found an increase in skeletal muscle mass (SMM), (<i>p<\/i> = 0.008; 0.008). In men, there was mainly a decrease in visceral fat area (VFA), (<i>p<\/i> = 0.028) and in women there was decrease of total body fat (TBF), (<i>p<\/i> = 0.020) and non-significant decrease of VFA (<i>p<\/i> = 0.098). SMM inversely correlated with VFA in men (<i>p<\/i> = \u20130.001) and with TBF in women (<i>p<\/i> = \u20130.005 ). GV was decreased generally and correlated inversely with TBF in men only (<i>p<\/i> = \u20130.026). Physical activity was increased and correlated inversely with VFA in men (<i>p<\/i> = \u20130.002) and in women (<i>p<\/i> = \u20130.006). <b><i>Conclusions:<\/i><\/b> Using CSII in T1D leads to a significant increase of SMM in both sexes to a decrease of VFA in men and to a non-significant decrease of VFA in women. Changes in adipose tissue and SMM were also related to increased physical activity and to decreased GV.<\/jats:p>","DOI":"10.1159\/000493734","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T22:01:27Z","timestamp":1544565687000},"page":"454-464","source":"Crossref","is-referenced-by-count":7,"title":["Insulin Pump Therapy \u2013 Influence on Body Fat Redistribution, Skeletal Muscle Mass and Ghrelin, Leptin Changes in T1D 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