{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:29:44Z","timestamp":1747193384336,"version":"3.40.5"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>Objective: To examine the distribution of risks for fetal trisomies after first-trimester combined screening in twins and to investigate different strategies for clinical implementation of cell-free DNA (cfDNA) testing. Methods: We retrospectively analyzed all twin pregnancies undergoing first-trimester combined screening over a 10 years\u2019 period. The population was stratified according to various risk cut-offs, and we examined different screening strategies for implementation of cfDNA testing in terms of impact on invasive testing rate, cfDNA test failure rate, and economic costs. Results: We included 572 twin pregnancies: 480 (83.92%) dichorionic and 92 (16.08%) monochorionic. Performing a first-line combined screening and offering cfDNA testing to the group with a risk between 1 in 10 and 1 in 1,000, would lead to an invasive testing rate of 2.45%, and cfDNA testing would be performed in 22.20% of the population. This strategy would be cost-neutral compared to universal combined screening alone. Conclusions: First-trimester combined screening results can be used to stratify twin pregnancies into different risk categories and select those that could be offered cfDNA testing. A contingent screening strategy would substantially decrease the need for invasive testing in twins and it would be cost-neutral compared to combined testing alone.<\/jats:p>","DOI":"10.1159\/000494055","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T22:01:32Z","timestamp":1542924092000},"page":"217-222","source":"Crossref","is-referenced-by-count":1,"title":["Screening for Common Fetal Trisomies in Twin Pregnancies: First-Trimester Combined, Cell-Free DNA, or Both?"],"prefix":"10.1159","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6733-7658","authenticated-orcid":false,"given":"Lucia","family":"Pasquini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Ponziani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Periti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Marchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Luchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Accurti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"D\u2019Ambrosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola\u00a0","family":"Persico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,11,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17283"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3934"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02222.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8845"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4431"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14664"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17484"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311037"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000358388"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15783"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12511"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14690"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18838"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15913"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15821"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17483"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12342"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4773"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15851"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/46\/4\/217\/3896777\/000494055.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/46\/4\/217\/3896777\/000494055.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:00:19Z","timestamp":1745427619000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000494055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,22]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,10,22]]},"published-print":{"date-parts":[[2019,10,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000494055","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2018,11,22]]}}}