{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:55:23Z","timestamp":1770843323347,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Intrauterine growth restriction (IUGR) is a poorly understood complication of pregnancy. It may be associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance, and end-stage renal disease<i>.<\/i> <b><i>Objectives:<\/i><\/b> The aim of this study was to check whether IUGR affects the function of renal tubules, as assessed by the tubular damage markers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1). <b><i>Methods:<\/i><\/b><i><\/i> The study included 126 term neonates. Thirty-eight newborns were the result of pregnancies complicated by IUGR. Eighty-eight healthy newborns were the result of normal pregnancies with no prenatal or perinatal complications. The concentrations of urinary NGAL and KIM-1 were determined with a commercially available ELISA kit and were normalized for urinary creatinine (Cr) concentration. <b><i>Results:<\/i><\/b> We found a significantly higher urinary concentration of NGAL and NGAL\/Cr ratio in newborns from pregnancies complicated by IUGR when compared to the reference group. We found that female gender was associated with a higher concentration of urinary NGAL and also urinary NGAL\/Cr. <b><i>Conclusions:<\/i><\/b> This is the first work that demonstrates that urinary NGAL concentration and urinary NGAL\/Cr are significantly higher in infants that are small for gestational age than in appropriate-for-gestational-age infants. This might indicate subclinical kidney damage in newborns with IUGR.<\/jats:p>","DOI":"10.1159\/000494102","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T22:01:41Z","timestamp":1543960901000},"page":"169-174","source":"Crossref","is-referenced-by-count":15,"title":["The Tubular Damage Markers: Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Newborns with Intrauterine Growth Restriction"],"prefix":"10.1159","volume":"115","author":[{"given":"Monika","family":"Kamianowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Szczepa\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta\u00a0Ewa","family":"Kulikowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Bebko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Wasilewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00033.2015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.715006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/136942"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4137\/CMPed.S40070"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s004670000457"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00173-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1377com"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000094538"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13726.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90601-C"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/PL00013427"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2002.01027.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000120681.61201.B4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1042\/bj3180001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0244-x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/364381"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.265"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm829"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.09.013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0824-z"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000263757"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182275164"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2015.09.003"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000357592"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1881"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:00:44Z","timestamp":1745427644000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000494102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,4]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,28]]},"published-print":{"date-parts":[[2019,3,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000494102","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,4]]}}}