{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:50:12Z","timestamp":1783648212111,"version":"3.55.0"},"reference-count":32,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> The prevalence of small intestine neuroendocrine tumors (SI-NETs) is increasing. Disease progression is often slow and treatment options and long-term survival rates have improved, but little is known about health-related quality of life (HRQoL) in these patients. <b><i>Objective:<\/i><\/b> To assess HRQoL and its predictors in SI-NET patients receiving contemporary treatments. <b><i>Methods:<\/i><\/b> We measured HRQoL with 15D and SF-36 questionnaires in 134 SI-NET patients and compared the 15D results to those of an age- and gender-standardized sample of the general population (<i>n<\/i> = 1,153). In the patients, we studied the impact of treatments, Ki-67, liver metastases, circulating tumor markers, comorbidities, and\/or socioeconomic factors on HRQoL with linear regression analysis. <b><i>Results:<\/i><\/b> The mean disease duration of the patients was 81 (4\u2013468) months, 91% had metastatic disease, and 79% received somatostatin analog treatment. Hepatic tumor load was 0% in 44.8%, &#x3c; 10\u201325% in 44.0%, and &#x3e; 25% in 11.2%, respectively. Mean fP-CgA and S-5HIAA concentrations were 15 (1.3\u2013250) and 344 (24\u20137,470) nmol\/L, respectively. Overall, HRQoL was significantly impaired in patients compared to controls (15D score 0.864 \u00b1 0.105 vs. 0.905 \u00b1 0.028, <i>p<\/i> &#x3c; 0.001). SI-NET patients scored worse on 9 of 15 dimensions: sleep, excretion (i.e., bladder and bowel function), depression, distress, vitality, sexual activity (<i>p<\/i> &#x3c; 0.001), breathing, usual activities, and discomfort and symptoms (<i>p<\/i> &#x3c; 0.01\u20130.05). SF-36 scores were impaired and highly correlated with 15D scores (<i>p<\/i> &#x3c; 0.001). HRQoL was impaired in patients with (<i>n<\/i> = 85) compared to patients without (<i>n<\/i> = 49) impaired excretion (0.828 vs. 0.933, <i>p<\/i> &#x3c; 0.001). In the patient group, number of medications predicted impaired HRQoL. <b><i>Conclusions:<\/i><\/b> Despite contemporary treatments, SI-NET patients have severely impaired HRQoL, including diarrhea, sleep, depression, vitality, and sexual activity.<\/jats:p>","DOI":"10.1159\/000494293","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T21:01:31Z","timestamp":1538773291000},"page":"366-374","source":"Crossref","is-referenced-by-count":15,"title":["Health-Related Quality of Life in Patients with Small Intestine Neuroendocrine Tumors"],"prefix":"10.1159","volume":"107","author":[{"given":"Noora","family":"Karppinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riikka","family":"Lind\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Sintonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maija","family":"Tarkkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto","family":"Roine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Heiskanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niina","family":"Matikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-0161","authenticated-orcid":false,"given":"Camilla","family":"Schalin-J\u00e4ntti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4377"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2010.12.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29099"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2014.941999"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002086"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X15613522"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-014-0787-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.8510"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316158"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.10.025"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/02841860152703445"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-5-18"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-009-9487-x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3182328045"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3189-z"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-018-4638-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000443167"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2016.03.002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.2780"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.46.4.370"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197307000-00013"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.46.1.88-a"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2016.1182210"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.016"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000113"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03366.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12967"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12550"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1530\/EC-15-0053"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:02:42Z","timestamp":1745427762000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000494293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,1,3]]},"published-print":{"date-parts":[[2019,1,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000494293","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.7370198","asserted-by":"subject"}]},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}