{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:47:57Z","timestamp":1761896877150,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Dietary sodium affects fluctuations in blood pressure (BP) and vascular function. Cardiotrophin-1 (CT-1), a stress-induced cytokine that belongs to the interleukin 6 family, is released by cells in response to potentially harmful stresses and plays a pivotal role in congestive heart failure, hypertension and arterial stiffness. In this study, we performed a randomized trial to confirm the effects of altered salt intake on the serum CT-1 levels in humans. <b><i>Methods:<\/i><\/b> Forty-four subjects (18\u201365 years of age) were selected from a rural community in northern China. All subjects initially maintained a baseline period for 3 days, transitioned to a low-salt (LS) diet for 7 days (3.0 g\/day of NaCl) and then a high-salt (HS) diet for an additional 7 days (18.0 g\/day of NaCl). <b><i>Results:<\/i><\/b> For the whole group, the serum CT-1 concentrations were significantly increased in the HS period compared to those of the LS period (293.50 \u00b1 137.70 vs. 360.40 \u00b1 162.83 pg\/mL, <i>p<\/i> = 0.040). The serum CT-1 concentrations significantly decreased from the baseline period to the LS diet (419.91 \u00b1 123.50 to 256.49 \u00b1 109.75 pg\/mL, <i>p<\/i> &#x3c; 0.01) and significantly increased from the LS to HS diet (256.49 \u00b1 109.75 to 414.39 \u00b1 191.21 pg\/mL, <i>p<\/i> &#x3c; 0.01). These changes were observed in salt-sensitive (SS) individuals but not in salt-resistant (SR) individuals. In addition, a significant positive relationship was observed between the changes in the CT-1 concentrations and systolic BP as well as the changes in the mean arterial pressure from the LS period to the HS period (<i>r<\/i> = 0.376, <i>p<\/i> = 0.012; <i>r<\/i> = 0.311, <i>p<\/i> = 0.040). The serum CT-1 concentrations were positively correlated with the 24-h urinary sodium-to-potassium (Na\/K) excretion ratios during both of the LS and HS diet intervention periods in SS subjects (<i>r<\/i> = 0.621, <i>p<\/i> &#x3c; 0.01), but this correlation was not evident in SR subjects (<i>r<\/i> = 0.208, <i>p<\/i> = 0.107). <b><i>Conclusions<\/i><\/b>: Our study indicates that variations in dietary salt intake affect the serum CT-1 levels in Chinese adults.<\/jats:p>","DOI":"10.1159\/000494436","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T22:04:56Z","timestamp":1541714696000},"page":"302-309","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Salt Intake on the Serum Cardiotrophin-1 Levels in Chinese Adults"],"prefix":"10.1159","volume":"73","author":[{"given":"Keke","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenling","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongbo","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,11,8]]},"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:04:33Z","timestamp":1745427873000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000494436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,12,6]]},"published-print":{"date-parts":[[2018,12,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000494436","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"type":"print","value":"0250-6807"},{"type":"electronic","value":"1421-9697"}],"subject":[],"published":{"date-parts":[[2018]]}}}