{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:39:54Z","timestamp":1776440394133,"version":"3.51.2"},"reference-count":40,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Mitochondrial dysfunction is implicated in the pathogenesis of multiple muscular diseases, including sporadic inclusion body myositis (s-IBM), the most common aging-related muscle disease. However, the factors causing mitochondrial dysfunction in s-IBM are unknown. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We hypothesized that resistance exercise (RE) may alleviate muscle impairment by improving mitochondrial function via reducing amyloid-beta (A\u03b2) accumulation. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Twenty-four male Wistar rats were randomized to a saline-injection control group (sham, &lt;i&gt;n&lt;\/i&gt; = 8), a chloroquine (CQ) control group (CQ-CON, &lt;i&gt;n&lt;\/i&gt; = 8), and a CQ plus RE group (CQ-RE, &lt;i&gt;n&lt;\/i&gt; = 8) in which rats climbed a ladder with weight attached to their tails 9 weeks after starting CQ treatment. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; RE markedly inhibited soleus muscle atrophy and muscle damage. RE reduced CQ-induced A\u03b2 accumulation, which resulted in decreased formation of rimmed vacuoles and mitochondrial-mediated apoptosis. Most importantly, the decreased A\u03b2 accumulation improved both mitochondrial quality control (MQC) through increased mitochondrial biogenesis and mitophagy, and mitochondrial dynamics. Furthermore, RE-mediated reduction of A\u03b2 accumulation elevated mitochondrial oxidative capacity by upregulating superoxide dismutase-2, catalase, and citrate synthase via activating sirtuin 3 signaling. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; RE enhances mitochondrial function by improving MQC and mitochondrial oxidative capacity via reducing A\u03b2 accumulation, thereby inhibiting CQ-induced muscle impairment, in a rat model of s-IBM.<\/jats:p>","DOI":"10.1159\/000494723","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T13:46:59Z","timestamp":1547560019000},"page":"240-252","source":"Crossref","is-referenced-by-count":21,"title":["Resistance Exercise Improves Mitochondrial Quality Control in a Rat Model of Sporadic Inclusion Body 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