{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:20:04Z","timestamp":1790050804956,"version":"4.0.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Spinal cord stimulation (SCS) is a well-established therapy for chronic pain syndromes, with growing applicability to other conditions. Restless legs syndrome (RLS) is a widespread, chronic movement disorder managed primarily and incompletely by medication, and its etiology can be classified as idiopathic or secondary. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Three patients underwent SCS implantation for chronic back and\/or leg pain with concomitant targeting of RLS: (1) a 34-year-old man with sporadic RLS symptoms that strongly intensified after military-related spinal fractures, (2) a 54-year-old man with RLS likely secondary to meralgia paresthetica, and (3) a 42-year-old man with low back and right lower extremity pain after a military motor vehicle accident. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Continuing through 40-month, 2-month, and 28-month follow-ups, respectively, the patients experienced exemplary relief of their RLS symptoms. Notably in the case of patient 1, this benefit appears separate from his pain relief, as during the 5-month period directly after surgery but before adjusted targeting, he only experienced pain alleviation. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; To our knowledge, this is the first reported case of using SCS as a potentially long-lasting, safe, and highly effective therapy for RLS of mixed etiology. Additionally, 2 patients with RLS possibly secondary to chronic pain also benefited from the therapy. This success may be due to increased inhibition from hypothalamic cells controlling dopaminergic input to the spine.<\/jats:p>","DOI":"10.1159\/000494737","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T21:00:50Z","timestamp":1554411650000},"page":"31-36","source":"Crossref","is-referenced-by-count":13,"title":["Spinal Cord Stimulation for Restless Legs Syndrome: Case Series and Mechanistic Hypothesis"],"prefix":"10.1159","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2322-5478","authenticated-orcid":false,"given":"Syed\u00a0M.","family":"Adil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u00a0L.","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth\u00a0A.","family":"Parente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivanand\u00a0P.","family":"Lad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-196707000-00025"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328365ab07"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.55"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.05.077"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2005.09.006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21207"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-404706-8.00006-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.12.029"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2014.06.008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.04.005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-014-0461-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318294b3f6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.11.012"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:07:21Z","timestamp":1745428041000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000494737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,5,7]]},"published-print":{"date-parts":[[2019,5,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000494737","archive":["Portico"],"relation":{},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}