{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:40:00Z","timestamp":1784720400045,"version":"3.55.0"},"reference-count":46,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury. <b><i>Methods:<\/i><\/b> NFL was measured in cerebrospinal fluid (CSF) (<i>n<\/i> = 130), preoperative serum (<i>n<\/i> = 192), and postoperative serum (<i>n<\/i> = 280) in hip fracture patients, and in CSF (<i>n<\/i> = 123) and preoperative serum (<i>n<\/i> = 134) in cognitively normal older adults undergoing elective surgery. Delirium was diagnosed with the Confusion Assessment Method. <b><i>Results:<\/i><\/b> Median serum NFL (pg\/mL) was elevated in delirium in hip fracture patients (94 vs. 54 pre- and 135 vs. 92 postoperatively, both <i>p<\/i> &#x3c; 0.001). Median CSF NFL tended to be higher in hip fracture patients with delirium (1,804 vs. 1,636, <i>p<\/i> = 0.074). Serum and CSF NFL were positively correlated (\u03c1 = 0.56, <i>p<\/i> &#x3c; 0.001). <b><i>Conclusion:<\/i><\/b> Our findings support an association between neuroaxonal injury and delirium. The correlation between serum and CSF NFL supports the use of NFL as a blood biomarker in future delirium studies.<\/jats:p>","DOI":"10.1159\/000494754","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T22:10:24Z","timestamp":1544134224000},"page":"346-357","source":"Crossref","is-referenced-by-count":60,"title":["Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium"],"prefix":"10.1159","volume":"46","author":[{"given":"Nathalie\u00a0Bodd","family":"Halaas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1890-4193","authenticated-orcid":false,"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane-Victoria","family":"Idland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torgeir\u00a0Bruun","family":"Wyller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"R\u00e6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frede","family":"Frihagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u00a0Cathrine","family":"Staff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0441-6700","authenticated-orcid":false,"given":"Leiv\u00a0Otto","family":"Watne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00101-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60688-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-12-63"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.07.024"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws190"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2015.12.004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/aft148"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07612.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2010.05.010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2326"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-9-21"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000481853"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14470"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13696"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12842"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8020033"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2010.10.006"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.06.012"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pjnns.2016.10.004"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000096644.08735.72"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.05.023"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.6.1337"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.06.030"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.9.1277"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512443092"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.07.007"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001015"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.3037"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004683"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12845"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-12-36"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.09.012"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.67052013.x"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2015-1195"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951517000104"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.05.019"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.3423"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4913"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.08.002"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005518"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081249"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.07.012"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.12067"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00070-3"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135886"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:07:27Z","timestamp":1745428047000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000494754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":46,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2019,1,17]]},"published-print":{"date-parts":[[2019,1,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000494754","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}