{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:30:51Z","timestamp":1783632651498,"version":"3.55.0"},"reference-count":16,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":2588,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 73-year-old female presenting with haemoptysis and dyspnoea was found to have a locally advanced left thyroid mass and vocal cord palsy. A CT scan of the neck and thorax and endoscopy demonstrated invasion into the tracheal lumen. Histopathology of the intraluminal tracheal mass confirmed a papillary thyroid cancer (PTC). The tumour was deemed unresectable due to local extent and patient comorbidities. TKI therapy with lenvatinib was used for 14 months. On serial scanning, a marked reduction in tumour volume from 31 \u00d7 59 \u00d7 32 mm to 17 \u00d7 28 \u00d7 22 mm was noted. This subsequently allowed a successful surgical resection with a total thyroidectomy and central neck dissection with no evidence of residual macroscopic disease. Histopathology confirmed a well-differentiated PTC with features of tumour regression. In this case, TKI therapy in a locally advanced unresectable DTC reduced tumour size and infiltration to a degree that surgical resection of macroscopic disease was possible, without requiring airway resection. This raises the possibility that TKIs may have a neoadjuvant role in selected cases of locally advanced DTC to reduce tumour volume and therefore morbidity of subsequent surgical resection.<\/jats:p>","DOI":"10.1159\/000494880","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T17:01:27Z","timestamp":1547744487000},"page":"102-107","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":37,"title":["Tyrosine Kinase Inhibitor Therapy in Locally Advanced Differentiated Thyroid Cancer: A Case Report"],"prefix":"10.1530","volume":"8","author":[{"given":"Kirsten\u00a0E.","family":"Stewart","sequence":"first","affiliation":[{"name":"1Department of Head and Neck Surgery, St John\u2019s Hospital at Howden, Livingston, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00a0W.J.","family":"Strachan","sequence":"additional","affiliation":[{"name":"2Metabolic Unit, Western General Hospital, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devraj","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"3Department of Oncology, Western General Hospital, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morna","family":"MacNeill","sequence":"additional","affiliation":[{"name":"4Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Wall","sequence":"additional","affiliation":[{"name":"3Department of Oncology, Western General Hospital, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8919-8783","authenticated-orcid":false,"given":"Iain\u00a0J.","family":"Nixon","sequence":"additional","affiliation":[{"name":"1Department of Head and Neck Surgery, St John\u2019s Hospital at Howden, Livingston, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"issue":"3","key":"2026070712582720500_ref1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1089\/thy.2010.0137","article-title":"The most commonly occurring papillary thyroid cancer in the United States is now a microcarcinoma in a patient older than 45 years","volume":"21","author":"Hughes","year":"2011","journal-title":"Thyroid","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"4","key":"2026070712582720500_ref2","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.amjsurg.2009.11.008","article-title":"Improved detection does not fully explain the rising incidence of well-differentiated thyroid cancer: a population-based analysis","volume":"200","author":"Morris","year":"2010","journal-title":"Am J Surg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9610","issn-type":"print"},{"issue":"6","key":"2026070712582720500_ref3","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.surg.2010.10.016","article-title":"Analysis of the rising incidence of thyroid cancer using the Surveillance, Epidemiology and End Results national cancer data registry","volume":"148","author":"Cramer","year":"2010","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"8","key":"2026070712582720500_ref4","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/0046-8177(93)90136-5","article-title":"Pathologic staging of papillary carcinoma of the thyroid with airway invasion based on the anatomic manner of extension to the trachea: a clinicopathologic study based on 22 patients who underwent thyroidectomy and airway resection","volume":"24","author":"Shin","year":"1993","journal-title":"Hum Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0046-8177","issn-type":"print"},{"issue":"3","key":"2026070712582720500_ref5","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.surg.2016.04.027","article-title":"Operative management of locally advanced, differentiated thyroid cancer","volume":"160","author":"Wang","year":"2016","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"10","key":"2026070712582720500_ref6","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1002\/hed.23619","article-title":"Management of invasive well-differentiated thyroid cancer: an American Head and Neck Society consensus statement. AHNS consensus statement","volume":"36","author":"Shindo","year":"2014","journal-title":"Head Neck","ISSN":"https:\/\/id.crossref.org\/issn\/1043-3074","issn-type":"print"},{"issue":"5","key":"2026070712582720500_ref7","first-page":"7","article-title":"Sequencing of tyrosine kinase inhibitors in progressive differentiated thyroid cancer","volume":"14","author":"Brose","year":"2016","journal-title":"Clin Adv Hematol Oncol","ISSN":"https:\/\/id.crossref.org\/issn\/1543-0790","issn-type":"print"},{"key":"2026070712582720500_ref8","unstructured":"National Institute for health and care excellence Clinical Guideline 2018. NICE Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine (ID 1059). Available at https:\/\/www.nice.org.uk\/guidance\/indevelopment\/gid-ta10101. Accessed May 1, 2018."},{"issue":"9940","key":"2026070712582720500_ref9","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0140-6736(14)60421-9","article-title":"Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial","volume":"384","author":"Brose","year":"2014","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"2026070712582720500_ref10","first-page":"18","article-title":"A phase 3, mulitcenter, double-blind, placebo-controlled trial of lenvatinib (E7080) in patients with 131-I-refractory differentiated thyroid cancer (SELECT)","volume":"32","author":"Shlumberger","year":"2014","journal-title":"J Clin Oncol","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"key":"2026070712582720500_ref11","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ctrv.2015.11.003","article-title":"Lenvatinib: role in thyroid cancer and other solid tumors","volume":"42","author":"Cabanillas","year":"2016","journal-title":"Cancer Treat Rev","ISSN":"https:\/\/id.crossref.org\/issn\/0305-7372","issn-type":"print"},{"issue":"2","key":"2026070712582720500_ref12","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3950\/jibiinkoka.118.115","article-title":"[Prognosis of papillary thyroid carcinoma with local invasion ] (Japanese)","volume":"118","author":"Yamada","year":"2015","journal-title":"Nippon Jibiinkoka Gakkai Kaiho","ISSN":"https:\/\/id.crossref.org\/issn\/0030-6622","issn-type":"print"},{"issue":"9","key":"2026070712582720500_ref13","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1089\/thy.2011.0535","article-title":"The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland","volume":"22","author":"Nixon","year":"2012","journal-title":"Thyroid","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"key":"2026070712582720500_ref14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ijscr.2017.10.010","article-title":"Surgical treatment of locally advanced papillary thyroid carcinoma after response to lenvatinib: A case report","volume":"41","author":"Tsuboi","year":"2017","journal-title":"Int J Surg Case Rep","ISSN":"https:\/\/id.crossref.org\/issn\/2210-2612","issn-type":"print"},{"issue":"12","key":"2026070712582720500_ref15","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1089\/thy.1998.8.1113","article-title":"Effectiveness of preoperative radioactive iodine (131I) therapy for locally advanced papillary thyroid cancer: a case report","volume":"8","author":"Shingu","year":"1998","journal-title":"Thyroid","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"2","key":"2026070712582720500_ref16","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1089\/thy.2012.0194","article-title":"Neoadjuvant chemotherapy in 16 patients with locally advanced papillary thyroid carcinoma","volume":"23","author":"Besic","year":"2013","journal-title":"Thyroid","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"}],"container-title":["European Thyroid Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/8\/2\/102\/34583\/etj494880.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/8\/2\/102\/34583\/etj494880.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:28:47Z","timestamp":1783445327000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article\/8\/2\/102\/4682\/Tyrosine-Kinase-Inhibitor-Therapy-in-Locally"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,17]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000494880","relation":{},"ISSN":["2235-0802","2235-0640"],"issn-type":[{"value":"2235-0802","type":"electronic"},{"value":"2235-0640","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,17]]}}}