{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:30:10Z","timestamp":1747193410913,"version":"3.40.5"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Objective:<\/i><\/b> Regarding cytological findings of squamous dysplasia, a comparison was made between a three-tiered classification \u2013 low-grade squamous intraepithelial lesion (LSIL), high-grade SIL\/cervical intraepithelial neoplasia 2 (HSIL\/CIN2), and HSIL\/CIN3 \u2013 and a two-tiered classification \u2013 LSIL and HSIL. The respective risk for CIN2+ and CIN3+ was calculated to make decisions regarding management. <b><i>Methods:<\/i><\/b> A total of 2,949 women with first-time cytologic findings of squamous dysplasia (LSIL, HSIL\/CIN2, or HSIL\/CIN3) between January 2013 and June 2016 were enrolled. Subsequent cytological findings and histological diagnoses were evaluated until August 2018. For each category of findings, the risk for CIN2+ and CIN3+ was determined by Kaplan-Meier estimates. The differences in risk between the cytological categories were checked for significance using the log-rank test. <b><i>Results:<\/i><\/b> For the categories LSIL, HSIL\/CIN2, and HSIL\/CIN3, the risk for CIN2+ after 12, 24, and 60 months was 3.4, 9.4, and 23.3%; 35.2, 44.8, and 59.8%; and 95.5, 97.8, and 98.9%, respectively. For CIN3+ the risk was 2.0, 5.5, and 13.5%; 28.6, 35.6, and 48.3%; 91.3, 95.6, and 97.9%, respectively. The differences in risk between the categories are highly significant, respectively (<i>p<\/i> &#x3c; 0.001). <b><i>Conclusion:<\/i><\/b> A three-tiered classification of squamous dysplasia such as the Munich Nomenclature III for cytology is suitable for risk-adapted clinical management, especially to avoid overdiagnosis and overtreatment.<\/jats:p>","DOI":"10.1159\/000494984","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T22:01:16Z","timestamp":1544047276000},"page":"44-49","source":"Crossref","is-referenced-by-count":3,"title":["Three-Tiered versus Two-Tiered Classification of Squamous Dysplasia in Cervical Cytology: Results of a Follow-Up Study"],"prefix":"10.1159","volume":"63","author":[{"given":"Katrin","family":"Marquardt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-4367","authenticated-orcid":false,"given":"Peter","family":"Ziemke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318287d329"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-0201-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00128360-200004040-00008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200301000-00003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200301000-00004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20018"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20973"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.LGT200570"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-011-1480-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001318.pub2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fe777f"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.12.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.069"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2017.1316973"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31818f5008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3182854269"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.09.012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k499"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-17-0293"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-017-0382-x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000343"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494984","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/494984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:09:50Z","timestamp":1745428190000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000494984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,5]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,2,20]]},"published-print":{"date-parts":[[2019,2,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000494984","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2018,12,5]]}}}