{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:58:32Z","timestamp":1778327912681,"version":"3.51.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Though Crohn\u2019s disease primarily affects the gastrointestinal tract, cutaneous Crohn\u2019s disease of the vulva can occur in the absence of gastrointestinal symptoms, complicating the diagnosis. Once clinicians suspect cutaneous Crohn\u2019s disease, antibiotics and traditional immunosuppressants comprise initial treatment. Unfortunately, sometimes these therapies are not effective, or they provide only short-lived symptomatic improvement. A few case reports have found tumor necrosis factor-\u03b1 inhibitors to be helpful in such refractory cases. We describe a patient with long-standing, painful vulvar Crohn\u2019s lesions with no gastrointestinal manifestations of the disease. Her diagnosis was delayed for years, and initial therapy with antibiotics and steroids was unsuccessful. Finally, the patient experienced effective and long-lasting symptom improvement with infliximab (Remicade&lt;sup&gt;TM&lt;\/sup&gt;).<\/jats:p>","DOI":"10.1159\/000495000","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T22:01:24Z","timestamp":1543442484000},"page":"263-267","source":"Crossref","is-referenced-by-count":9,"title":["Delayed Diagnosis of Vulvar Crohn\u2019s Disease in a Patient with No Gastrointestinal Symptoms"],"prefix":"10.1159","volume":"10","author":[{"given":"Leah\u00a0Ellis","family":"Wells","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.10.009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv037"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5847\/wjem.j.1920-8642.2017.04.011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/737640"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20853"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00573.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2009.09.012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02710.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8192150"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/09593985.2015.1038375"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:09:57Z","timestamp":1745428197000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000495000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,28]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,1,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000495000","archive":["Portico"],"relation":{},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,28]]}}}