{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T16:22:43Z","timestamp":1750004563198,"version":"3.40.4"},"reference-count":29,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Human cosaviruses (HCoSVs) are newly discovered enteric viruses in the Picornaviridae family. They have been described in non-polio acute flaccid paralysis, diarrheal patients, and healthy individuals. They remain rarely documented in immunodeficient patients. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; This study reports iterative excretion of HCoSVs in a patient with major histocompatibility complex (MHC) class II combined immunodeficiency, a relatively common primary immunodeficiency in consanguineous settings. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 35 samples were collected from a patient followed for oral polio vaccine strains detection in stool samples during a 57-month period. Detection of HCoSVs in stools was performed by nested RT-PCR in the 5\u2032 noncoding region. The genotype identification and screening for recombinant strains was performed by sequencing in the VP1 and 3D genomic regions followed by phylogenetic analysis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The patient was infected with HCoSVs twice at a 3-year interval. The excreted viruses belonged to 2 different genotypes with 2 probable recombinant viruses. During HCoSV infections, the patient was also excreting Sabin-related polioviruses. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; This study describes excretion kinetics and genetic characteristics of HCoSVs in a patient with combined immunodeficiency due to MHC class II expression defect. The patient did not have concomitant symptoms related to the HCoSV infection.<\/jats:p>","DOI":"10.1159\/000495182","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T22:01:14Z","timestamp":1549490474000},"page":"247-254","source":"Crossref","is-referenced-by-count":2,"title":["Iterative Excretion of Human Cosaviruses from Different Genotypes Associated with Combined Immunodeficiency Disorder"],"prefix":"10.1159","volume":"61","author":[{"given":"Asma","family":"Lamari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henda","family":"Triki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Driss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henda","family":"Touzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zina","family":"Meddeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahlem","family":"Ben\u00a0Yahia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed-Ridha","family":"Barbouche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorra","family":"Rezig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2017.05.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807979105"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02301-08"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036685"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.053827-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24076"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-016-0630-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-5-159"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.03.024"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01427-12"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2017.02.018"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-011-0700-y"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3201\/eid1804.111415"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.04.023"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12560-013-9120-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2015.03.004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01062-09"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1021\/es305181x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-015-2435-x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-015-2637-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2014.06.011"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00293-12"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01122-14"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00685"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-013-9863-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3201\/eid1910.130352"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst197"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-22"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.457"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:11:36Z","timestamp":1745428296000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000495182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,4,11]]},"published-print":{"date-parts":[[2019,4,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000495182","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"type":"print","value":"0300-5526"},{"type":"electronic","value":"1423-0100"}],"subject":[],"published":{"date-parts":[[2018]]}}}