{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:36:35Z","timestamp":1792794995283,"version":"4.5.0"},"reference-count":97,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Psoriasis is a common, chronic inflammatory skin disorder, which can significantly impact quality of life. Despite major breakthroughs in our understanding of the pathogenesis of psoriasis, the chronological order of the underlying mechanisms leading to the development of psoriatic plaques remains to be completely understood. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; Although psoriasis is classically perceived as a T-cell disease, it is now well recognized that T lymphocytes do not function in exclusivity. This theory is supported by evidence from transgenic murine models that develop marked psoriasiform disease. In addition, immune cells and cytokines regulate both early and late events involved in the pathogenesis of psoriasis. &lt;b&gt;&lt;i&gt;Key Messages:&lt;\/i&gt;&lt;\/b&gt; Psoriasis is a complex disease \u2013 a dynamic interplay between immune cells, keratinocytes, and various other skin-resident cells, such as endothelial and immune cells. The contribution of each cell type is crucial in the initiation and maintenance phases of psoriatic alterations.<\/jats:p>","DOI":"10.1159\/000495291","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T22:01:12Z","timestamp":1545256872000},"page":"91-100","source":"Crossref","is-referenced-by-count":200,"title":["Psoriasis: Keratinocytes or Immune Cells \u2013 Which Is the Trigger?"],"prefix":"10.1159","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-8297","authenticated-orcid":false,"given":"Farida","family":"Benhadou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3705-0119","authenticated-orcid":false,"given":"Dillon","family":"Mintoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"del\u00a0Marmol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.033217"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-35"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1985.tb15259.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.04.035"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12710"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.11.1447"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.62751"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.6.080604.162324"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-355982"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197210122871503"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10895.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1086\/301899"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071690"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70188-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2010.10013"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12961"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115633"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050500"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/ni1112"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141126"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.3059"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.12.1490"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13236"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/nature03547"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6621"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/nature06116"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.262"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.194"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509736102"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4917"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3895"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1908"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.879093"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.09.008"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.11.005"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.001"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60726-6"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13932"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0143-7"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109997"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2015.1045410"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2004.03.011"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.12.9.1085"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12050"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8652"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(91)90081-U"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197909063011015"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(86)90005-8"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.28.020177.002343"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1613"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1767"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701213"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101824"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1822"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.164"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.3390\/diseases6020047"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb14769.x"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80132-4"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.08.013"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118989"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90190-2"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12363613"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.7.3465"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6621"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1086\/503821"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.4.1013"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1007\/BF01718309"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1747.2003.12630.x"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23459.x"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05287.x"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6137"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1038\/nature00820"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.92979"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118797"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001227"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.4172\/2376-0427.1000244"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.076919"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13378"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090480"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2009.01.004"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2009.00669.x"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.03.023"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1038\/nature10525"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.12.046"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008383"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1965.126"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01311.x"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22719.x"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12668098"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1038\/nature03963"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907550106"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.11.011"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.13.6076"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00390.x"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120568"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.08.014"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:13:05Z","timestamp":1745428385000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000495291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":97,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,21]]},"published-print":{"date-parts":[[2019,2,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000495291","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,19]]}}}