{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:25:01Z","timestamp":1765232701895,"version":"3.40.5"},"reference-count":28,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Peripheral T cell lymphoma (PTCL) is a heterogeneous entity with poor survival. We evaluated the neutrophil-to-lymphocyte ratio (NLR), absolute lymphocyte count (ALC), and platelet count as new prognostic factors for PTCL. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; We retrospectively analyzed 77 patients with PTCL initially treated with anthracycline-based chemotherapy. Survival curves were compared between groups with different initial NLR (iNLR), end-point NLR (eNLR), initial ALC, and platelet counts. Cox regression was used to analyze the risk factor for survival. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Patients with a higher eNLR (\u22653), lymphopenia (&amp;#x3c; 1,000\/\u03bcL), and thrombocytopenia (&amp;#x3c; 150 K\/\u03bcL) had an inferior progression-free survival (PFS) and overall survival (OS) compared to their counterparts, while a higher iNLR (\u22653) was predictive of a shorter OS but not PFS. Among these, thrombocytopenia was an independent poor prognostic factor for both PFS and OS, with a hazard ratio of 2.42 (&lt;i&gt;p&lt;\/i&gt; = 0.012) for PFS and 4.21 (&lt;i&gt;p&lt;\/i&gt; = 0.006) for OS. The presence of thrombocytopenia further stratified patients with a worse prognosis within overlapping risk-groups by the prognostic index for PTCL. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Our study showed that thrombocytopenia at diagnosis was an independent prognostic factor for survival in patients with PTCL.<\/jats:p>","DOI":"10.1159\/000495337","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T06:51:04Z","timestamp":1551336664000},"page":"176-186","source":"Crossref","is-referenced-by-count":16,"title":["Prognostic Value of Platelet Count in Patients with Peripheral T Cell Lymphoma"],"prefix":"10.1159","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5576-7610","authenticated-orcid":false,"given":"Mihong","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Ok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongheon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u00a0Yun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyewon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Mee","family":"Bang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon\u00a0Seok","family":"Eom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u00a0Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008265532487"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh409"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-231548"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3080"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq359"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21849"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.982642"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju124"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1045897"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.100"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3845"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq314"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23205"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.508189"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2012.23"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2188-8"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2011.09.215"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2009.06.014"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-4-34"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685796"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.53289"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.691482"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-692566"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:13:26Z","timestamp":1745428406000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000495337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,4,4]]},"published-print":{"date-parts":[[2019,4,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000495337","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2019]]}}}