{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:44:45Z","timestamp":1780609485585,"version":"3.54.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> In patients with chronic kidney disease (CKD) strict blood pressure (BP) control is reno-protective. However, renal benefits from BP control might depend also on the etiology of CKD. We investigated if maintenance of BP at target is equally effective in subjects with hypertensive nephropathy (HN+) and in those with other nephropathies (HN-). <b><i>Methods:<\/i><\/b> We evaluated 148 patients with CKD (stages 3-5) in two visits at least 12 months apart. BP was measured both as office BP and 24h ambulatory blood pressure (ABP). Glomerular filtration rate (eGFR) was estimated with CKD-EPI formula. The slope of eGFR variation (\u0394eGFR) was calculated as: (eGFR1-eGFR0)\/months of follow up. <b><i>Results:<\/i><\/b> Cohort characteristics were: HN-(n=82) and HN+ (n=66), age (71\u00b19 vs 74\u00b19 years; p=0.09); prevalence of diabetes (57 vs 43%; p=0.19); average follow up (19\u00b17 vs 21\u00b19 months; p=0.3). HN- and HN+ did not differ regarding both baseline eGFR (34\u00b118 vs 35\u00b114 ml\/min; p=0.97) and \u0394eGFR (0.00\u00b10.53 vs -0.06\u00b10.35 ml\/min\/month, p=0.52). The proportion of patients with BP at target at both visits was similar in HN- and HN+ (office BP: HN- 18% and HN+ 27%; p=0.21; ABP: HN- 42% and HN+ 43; p=0.96). In patients with office BP at target at both visits HN- showed a significant improvement of \u0394eGFR respect to HN+ (HN-: 0.240 \u00b1 0.395 and HN+: -0.140\u00b10.313 ml\/min\/ month; p=0.026). In patients with office BP not at target HN- and HN+ did not show any difference in \u0394eGFR (HN- 0.00\u00b10.47; HN+ -0.030\u00b10.420 ml\/min\/month; p=0.66). ABP was not associated with differences in \u0394eGFR either if it was at target (HN- 0.104\u00b10.383 and HN+ 0.00\u00b10.476 ml\/min\/month; p=0.42) or not (HN- -0.057\u00b10.503 and HN+ -0.092\u00b10.325 ml\/ min\/month; p=0.87). <b><i>Conclusion:<\/i><\/b> In patients with CKD and HN+ maintenance of BP targets recommended by current guidelines is less reno-protective than it is in HN-.<\/jats:p>","DOI":"10.1159\/000495388","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T22:03:44Z","timestamp":1543010624000},"page":"1706-1715","source":"Crossref","is-referenced-by-count":11,"title":["Patients with Hypertensive Nephropathy and Chronic Kidney Disease Might Not Benefit from Strict Blood Pressure Control"],"prefix":"10.1159","volume":"43","author":[{"given":"Simone","family":"Vettoretti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Caldiroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Zanoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Azzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Villarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Meazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piergiorgio","family":"Messa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,11,23]]},"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:13:45Z","timestamp":1745428425000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000495388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,12,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000495388","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}