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Novel immunotherapies targeting CD19, including the bispecific T-cell engager blinatumomab and chimeric antigen-receptor T (CAR-T) cells, have revolutionized the treatment of R\/R B-ALL. Robust response rates to CAR-T cell therapy after blinatumomab have recently been reported, but it is unknown whether blinatumomab can be effective following failure of anti-CD19 CAR-T cell therapy. Herein, we describe a patient with Philadelphia chromosome-positive B-ALL who relapsed after CD19-directed CAR-T therapy, but subsequently responded to the combination of blinatumomab and the tyrosine kinase inhibitor ponatinib, with the achievement of a complete remission lasting 12 months.<\/jats:p>","DOI":"10.1159\/000495558","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T22:08:32Z","timestamp":1548799712000},"page":"107-110","source":"Crossref","is-referenced-by-count":18,"title":["Relapsed Philadelphia Chromosome-Positive Pre-B-ALL after CD19-Directed CAR-T Cell Therapy Successfully Treated with Combination of Blinatumomab and Ponatinib"],"prefix":"10.1159","volume":"141","author":[{"given":"Firas","family":"El\u00a0Chaer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noa\u00a0G.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward\u00a0A.","family":"Sausville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennie\u00a0Y.","family":"Law","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u00a0Tae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vu\u00a0H.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9499-1348","authenticated-orcid":false,"given":"Maria\u00a0R.\u00a0","family":"Baer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rima","family":"Koka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeba\u00a0N.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy\u00a0M.","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashkan","family":"Emadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1182\/blood-2006-05-018192"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.3324\/haematol.2009.014274"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1038\/sj.leu.2404824"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1002\/(SICI)1097-0142(19991001)86:7<1216::AID-CNCR17>3.0.CO;2-O"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1056\/NEJMoa1609783"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1200\/JCO.2016.69.3531"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1056\/NEJMoa1709919"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1158\/2159-8290.CD-15-1020"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1038\/ncomms12320"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1182\/blood-2015-08-665547"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1002\/pbc.25953"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1182\/blood-2016-05-718395"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1182\/blood-2017-05-782888"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1200\/JCO.2018.36.15_suppl.7006"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1182\/blood-2011-05-349191"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1056\/NEJMoa1407222"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.2147\/OTT.S70524"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1056\/NEJMoa1306494"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1111\/bjh.14222"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1158\/1535-7163.MCT-12-0302"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1016\/j.clml.2017.08.101"}],"container-title":["Acta 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