{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:23:36Z","timestamp":1790375016135,"version":"4.1.0"},"reference-count":31,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord Extra"],"abstract":"<b><i>Background:<\/i><\/b> Few studies have assessed smoking and obesity together as risk factors for frontotemporal dementia (FTD) and Alzheimer\u2019s disease (AD). <b><i>Objective:<\/i><\/b> To study smoking and obesity as risk factors for FTD and AD. <b><i>Methods:<\/i><\/b> Ninety patients with FTD and 654 patients with AD were compared with 116 cognitively healthy elderly individuals in a longitudinal design with 15\u201331 years between measurements of risk factors before the dementia diagnosis. <b><i>Results:<\/i><\/b> There were no associations between smoking and FTD (<i>p<\/i> = 0.218; odds ratio [OR]: 0.990; 95% confidence interval [CI]: 0.975\u20131.006). There were significant associations between obesity and FTD (<i>p<\/i> = 0.049; OR: 2.629; 95% CI: 1.003\u20136.894). There were significant associations between both smoking (<i>p<\/i> = 0.014; OR: 0.987; 95% CI: 0.977\u20130.997) and obesity (<i>p<\/i> = 0.015; OR: 2.679; 95% CI: 1.211\u20135.928) and AD. <b><i>Conclusion:<\/i><\/b> Our findings suggest that obesity is a shared risk factor for FTD and AD, while smoking plays various roles as a risk factor for FTD and AD.<\/jats:p>","DOI":"10.1159\/000495607","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T22:05:42Z","timestamp":1547071542000},"page":"1-10","source":"Crossref","is-referenced-by-count":22,"title":["Smoking and Obesity as Risk Factors in Frontotemporal Dementia and Alzheimer\u2019s Disease: The HUNT 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