{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:32:32Z","timestamp":1761514352169,"version":"3.40.5"},"reference-count":38,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Second primary malignancies (SPM) in the lung are not common in breast cancer (BC) patients. <i>EGFR<\/i>-mutant lung cancer (LC) is a separate molecular subset, and the co-existence of <i>EGFR<\/i>-mutant LC and BC has not been explored. We hypothesized that <i>EGFR<\/i>-mutant LC patients could have higher rates of primary BC than those with <i>EGFR-<\/i>wild type (WT). <b><i>Methods:<\/i><\/b> We collected data on clinical and molecular characteristics and outcomes of female patients with LC and a previous or simultaneous history of primary BC treated in our hospital from 2008 to 2014. <b><i>Results:<\/i><\/b> Data on treatment, follow-up, and <i>EGFR<\/i> mutation status were available for 356 patients. 17.7% (11\/62) of patients with <i>EGFR<\/i> mutations had BC, compared to 1.02% (3\/294) of <i>EGFR-<\/i>WT patients (<i>p<\/i> < 0.001). Both tumors were metachronous in 81.8%, with LC diagnosed 9 years after the diagnosis of BC. 5 of the 6 (83.3%) BC patients treated with radiotherapy developed LC in an area within the radiation field. No <i>EGFR<\/i> mutations were detected in BC tissue and no HER2 expression was detected in LC samples. <b><i>Conclusion:<\/i><\/b> SPM in the lung and breast occur more frequently among <i>EGFR<\/i>-mutant compared to <i>EGFR<\/i>-WT LC patients. Radiotherapy for BC may increase the risk of developing primary LC.<\/jats:p>","DOI":"10.1159\/000495666","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T07:04:42Z","timestamp":1551078282000},"page":"107-114","source":"Crossref","is-referenced-by-count":3,"title":["A Single-Center Retrospective Study of Patients with Double Primary Cancers: Breast Cancer and <b><i>EGFR<\/i><\/b>-Mutant Non-Small Cell Lung 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