{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:36:43Z","timestamp":1783489003048,"version":"3.55.0"},"reference-count":58,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>Hypogonadism after treatment for childhood cancer is a recognized complication and its cause may be subdivided into primary gonadal failure and central hypogonadism. Here, we provide an overview of the risk factors for the development of hypogonadism, assessment and potential interventions and give a summary of the current recommendations for management and follow-up of hypogonadism in childhood cancer survivors.<\/jats:p>","DOI":"10.1159\/000495943","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T22:01:22Z","timestamp":1548972082000},"page":"93-103","source":"Crossref","is-referenced-by-count":31,"title":["Hypogonadism in Children with a Previous History of Cancer: Endocrine Management and Follow-Up"],"prefix":"10.1159","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6931","authenticated-orcid":false,"given":"Hanneke\u00a0M.","family":"van\u00a0Santen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marry\u00a0M.","family":"van\u00a0den\u00a0Heuvel-Eibrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne\u00a0D.","family":"van\u00a0de\u00a0Wetering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.\u00a0Hamish","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.4647"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.3268"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109\/14647273.2012.733480"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1109290"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2017.11.004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.3441"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30026-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(05)80321-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2016.0007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00039-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.3288"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24679"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.11.038"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2018.1455498"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60355-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.1914"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24445"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt062"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det442"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12921"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/2042018817746291"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70334-1"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev128"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f1190"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29181"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1530\/EC-17-0382"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.76"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.3839"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70408-5"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem313"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01712.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.7038"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2011.01167.x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181377"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.10.047"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev190"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex306"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey240"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000370"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.6545"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.7933"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-016-2124-5"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.5025"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1435-x"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.2217\/WHE.14.82"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03868.x"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgi022"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01031-4"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.169"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0430"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.126516"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13164"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.9037"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.1541"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70251-1"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey216"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.0582"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31121"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/495943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:20:04Z","timestamp":1745428804000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000495943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,6,28]]},"published-print":{"date-parts":[[2019,7,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000495943","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}