{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:40:14Z","timestamp":1783975214595,"version":"3.55.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background and Aims:<\/i><\/b> Proton pump inhibitors are effective at reducing heartburn. No studies have evaluated their efficacy in Ramadan. Dexlansoprazole has a unique active formulation independent of time-of-day dosing or food. The aim is to investigate the efficacy of dexlansoprazole 60 mg during Ramadan in patients with symptomatic heartburn. <b><i>Methods:<\/i><\/b> Subjects recruited using poster, radio, and SMS advertisements completed a diary using a mobile-friendly application and received daily SMS reminders. Dexlansoprazole was started on day 8 for 3 weeks. No placebo arm was used in this trial. Primary endpoint was relief of heartburn expressed as mean 24-h free heartburn percentage (24FH%) per weekly period. <b><i>Results:<\/i><\/b> A total of 32 patients were enrolled. During week 1, only 1 person (3.1%) was heartburn-free and mean 24FH% was 41.1 \u00b1 24.8%. On dexlansoprazole, mean 24FH% rose to 63.4 \u00b1 23.8 and 81.6 \u00b1 24.5% in weeks 2 and 4, respectively (<i>p<\/i> &#x3c; 0.001 for both). Median 24FH% increased from 35.7% in week 1 to 71.4 and 85.7% in weeks 2 and 4, respectively. Mean Gastroesophageal Reflux Disease Questionnaire (GERDQ) scores decreased from 10.0\u00a0\u00b1 3.2 in week 1 to 6.53 \u00b1 2.2 in week 2 (<i>p<\/i> &#x3c; 0.001) and 5.87 \u00b1 2.1 in week 4 (<i>p<\/i> &#x3c; 0.001). Mean heartburn severity score decreased from 2.5 \u00b1 1.0 to 1.7 \u00b1 0.8 (<i>p<\/i> = 0.001). Early response was higher in patients with GERDQ scores \u22658 (<i>p<\/i> = 0.012). <b><i>Conclusion:<\/i><\/b> Dexlansoprazole is effective in the treatment of heartburn during Ramadan. Clinicaltrials.gov number: NCT03079050.<\/jats:p>","DOI":"10.1159\/000496091","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T22:05:44Z","timestamp":1547071544000},"page":"188-193","source":"Crossref","is-referenced-by-count":2,"title":["Dexlansoprazole is Effective in Relieving Heartburn during the Fasting Month of Ramadan"],"prefix":"10.1159","volume":"37","author":[{"given":"Hussein\u00a0H.","family":"Rimmani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luma\u00a0Basma\u00a0O.","family":"Rustom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud\u00a0A.","family":"Rahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rani\u00a0H.","family":"Shayto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Chaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0248-9527","authenticated-orcid":false,"given":"Ala\u00a0I.","family":"Sharara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,1,9]]},"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:20:59Z","timestamp":1745428859000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000496091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,2,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000496091","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}