{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:36:19Z","timestamp":1777451779477,"version":"3.51.4"},"reference-count":43,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The combination of growth hormone (GH) and aromatase inhibitors (AI) improves linear growth in severely short adolescent boys; however, the effects of this intervention on quality of life (QoL) are unknown. This study assesses whether GH, AI, or their combination impacts the QoL of adolescent males with idiopathic short stature (ISS) from both the adolescent and the parent perspective. &lt;b&gt;&lt;i&gt;Method:&lt;\/i&gt;&lt;\/b&gt; A randomized open-label comparator trial was conducted in 76 pubertal males with ISS who received AI, GH, or AI\/GH for 24 months. The condition-specific Quality of Life in Short Stature Youth questionnaire was used to assess QoL. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; QoL scores were low at baseline in the children\u2019s and parents\u2019 reports. Within-group testing showed that total QoL scores increased significantly at 24 months in the GH and AI\/GH group but not the AI group in the children\u2019s report, whereas it increased in all of the groups in the parents\u2019 report. Increases in QoL scores were associated with an increase in height SDS. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Treatment with GH and AI\/GH was associated with improved QoL scores as measured from both the patients\u2019 and the parents\u2019 perspectives, suggesting that the improved growth resulting from the use of these growth-promoting therapies has beneficial psychosocial effects in adolescent males with ISS followed for 24 months.<\/jats:p>","DOI":"10.1159\/000496353","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T08:53:19Z","timestamp":1551430399000},"page":"381-392","source":"Crossref","is-referenced-by-count":16,"title":["Quality of Life in Adolescent Boys with Idiopathic Short Stature: Positive Impact of Growth Hormone and Aromatase 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