{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T14:57:50Z","timestamp":1767884270103,"version":"3.49.0"},"reference-count":36,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Innate Immun"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>To investigate the role of fatty acid-binding protein 5 (FABP5) in infectious diseases, FABP5-deficient mice were challenged with &lt;i&gt;Listeria monocytogenes&lt;\/i&gt;, a facultative intracellular bacterial pathogen. Interestingly, FABP5-deficient animals were able to clear the infection within 3 days whereas control wild-type (WT) animals showed comparatively higher bacterial burdens in the liver and spleen. Sections of infected tissues showed an increase in inflammatory foci in WT mice compared to FABP5-deficient mice. FABP5-deficient mice had lower circulating inflammatory cytokines and increased inducible nitric oxide synthase production. FABP5-deficient mouse bone marrow-derived macrophages produced higher levels of nitrite anion than their WT counterparts in response to various stimuli. Additionally, in contrast to FABP5&lt;sup&gt;\u2013\/\u2013&lt;\/sup&gt; mice, transgenic mice overexpressing FABP5 in myeloid cells (LysM-Cre driven) showed decreased survival rates and increased bacterial burden and inflammatory cytokines. Overall, these findings suggest that increased FABP5 levels correlate with a higher &lt;i&gt;L. monocytogenes&lt;\/i&gt; bacterial burden and elevated subsequent inflammation.<\/jats:p>","DOI":"10.1159\/000496405","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T22:00:34Z","timestamp":1552946434000},"page":"469-480","source":"Crossref","is-referenced-by-count":11,"title":["Mice Lacking Fatty Acid-Binding Protein 5 Are Resistant to &lt;b&gt;&lt;i&gt;Listeria 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