{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:53:35Z","timestamp":1760550815895,"version":"3.40.5"},"reference-count":33,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The widespread use of rapid on-site evaluation is hampered by constraints related to time and resources, inadequate reimbursement, and evidence from randomized trials that show a lack of increase in diagnostic yield and specimen adequacy associated with its usage. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We aimed to verify whether a pulmonologist can assess endosonography-derived lymph node samples after a comprehensive and reproducible training provided by a specialist pathologist. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt;Prospective, observational trial structured in three phases. In the first (training) phase, a pathologist critically evaluated the smears from 150 archival endosonography cases with a pulmonologist. In the second (test) phase, the pulmonologist was asked to assess 50 archival endosonography-derived samples. In the last (real-life) phase, the pulmonologist classified the samples from 200 patients during the endosonography. The overall agreement between pulmonologist and pathologist (gold standard), assessed through \u03ba-statistics, was the primary outcome. The agreement for the identification of specific cytological categories was the secondary outcome. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The overall&lt;b&gt;&lt;i&gt;&lt;\/i&gt;&lt;\/b&gt;agreement between pulmonologist and pathologist was 84% (\u03ba&lt;i&gt;&lt;\/i&gt;0.765, 95% CI 0.732\u20130.826) in the test phase and 89.7% (\u03ba 0.844, 95% CI 0.799\u20130.881) in the real-life phase. The agreement for specific cytological categories was 92.7% (95% CI 0.824\u20130.980) for inadequate samples, 90.3% (95% CI 84.5\u201394.5%) for reactive lymphadenopathies, 90.5% (95% CI 0.845\u20130.946) for malignancy, and 73% (95% CI 0.515\u20130.897) for granulomatous samples. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; A trained pulmonologist can reliably assess adequacy and malignancy for endosonography-derived samples, which could be useful in institutions where a cytopathologist\/cytotechnician is not available regularly.<\/jats:p>","DOI":"10.1159\/000496549","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T21:00:29Z","timestamp":1555102829000},"page":"540-547","source":"Crossref","is-referenced-by-count":8,"title":["A Trained Pulmonologist Can Reliably Assess Endosonography-Derived Lymph Node Samples during Rapid On-Site Evaluation"],"prefix":"10.1159","volume":"97","author":[{"given":"Filippo","family":"Natali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Cancellieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Tinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"De\u00a0Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanina","family":"Livi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micaela","family":"Romagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Paioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-4696","authenticated-orcid":false,"given":"Rocco","family":"Trisolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0114-SA"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21215"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2013.838017"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000084041"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1521"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0b013e31821707ee"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000346987"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0583"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.11.004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPEGZMJKC42VUP"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0025-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000368857"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1216"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000084050"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.71740"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.71741"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.9046"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201107-1199CI"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21320"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0756"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21637"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-7396-2"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.11.014"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0001-6"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12122"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-865020150070000009"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.047829"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1.122"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-699X.2010.00232.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1159\/000475843"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2768"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1710"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:10:49Z","timestamp":1745424649000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000496549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,21]]},"published-print":{"date-parts":[[2019,6,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000496549","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.7987046","asserted-by":"subject"}]},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2019]]}}}