{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:31:00Z","timestamp":1747193460624,"version":"3.40.5"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>A 37-year-old male was admitted with an atypical presentation of central nervous system (CNS) aspergillosis while on ibrutinib therapy for a CNS relapse of mantle cell lymphoma. This case highlights the importance of a high clinical suspicion of opportunistic infections in patients receiving small-molecule kinase inhibitors. This report includes a review of reported cases of &lt;i&gt;Aspergillus&lt;\/i&gt; infections in patients receiving ibrutinib and the shared features of these cases&lt;i&gt;.&lt;\/i&gt;<\/jats:p>","DOI":"10.1159\/000496555","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T22:06:20Z","timestamp":1554329180000},"page":"209-213","source":"Crossref","is-referenced-by-count":5,"title":["The Muddied Waters of Ibrutinib Therapy"],"prefix":"10.1159","volume":"141","author":[{"given":"Miri","family":"Schamroth\u00a0Pravda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0989-187X","authenticated-orcid":false,"given":"Nili","family":"Schamroth\u00a0Pravda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lishner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0808853"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy175"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306220"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1248965"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix687"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-818286"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08549.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.04.012"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281170"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061098"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061094"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007394.pub2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2429-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2017.03.011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1320710"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-603670"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400376"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2387"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1600328"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30632-5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/1078155218788717"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1494271"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.028"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1485913"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:10:51Z","timestamp":1745424651000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000496555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,5,15]]},"published-print":{"date-parts":[[2019,5,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000496555","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2019]]}}}