{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:02:22Z","timestamp":1782831742005,"version":"3.54.5"},"reference-count":28,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Objective:<\/i><\/b> <i>Helicobacter pylori<\/i> eradication is expected to prevent gastric cancer. However, morphological alterations after eradication often hinder accurate diagnosis. Therefore, we evaluated endoscopic and histological changes in gastric tumors after eradication of <i>H. pylori<\/i> in a time-dependent manner. <b><i>Methods:<\/i><\/b> We classified 144 cases of endoscopic submucosal dissection (ESD) of early gastric cancer into the following categories: (i) patients positive for <i>H. pylori<\/i> with no eradication history<i>,<\/i> (ii) patients positive for <i>H. pylori<\/i> who underwent ESD 2 months after eradication, (iii) patients negative for <i>H. pylori<\/i> with an eradication history of at least 6 months before ESD, and (iv) patients negative for <i>H. pylori<\/i> with an unknown history. We compared endoscopic and histological factors between the groups. <b><i>Results:<\/i><\/b> The characteristics of cancers positive for <i>H. pylori<\/i> were exploding shape, superficial high-grade atypical epithelium, and a surface proliferating zone. <i>H. pylori<\/i> eradication induced a series of endoscopic and histological changes, including shape \u00addepression, appearance of surface regenerative and lower-grade atypical epithelium, and a downward shift of the proliferative zone within a period as short as 2 months. <b><i>Conclusion:<\/i><\/b> <i>H. pylori<\/i> eradication rapidly causes cancer regression and leads to tumor shrinkage, diminished atypism, and shortened proliferative zone, resulting in drastic morphological changes.<\/jats:p>","DOI":"10.1159\/000496692","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T22:00:32Z","timestamp":1553119232000},"page":"135-144","source":"Crossref","is-referenced-by-count":8,"title":["Eradication of <b><i>Helicobacter pylori<\/i><\/b> Induces Immediate Regressive Changes in Early Gastric Adenocarcinomas"],"prefix":"10.1159","volume":"86","author":[{"given":"Mitsuru","family":"Nakagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Kiriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomitsu","family":"Tahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Horiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asako","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayumi","family":"Tahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ohmiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sugioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7502-8724","authenticated-orcid":false,"given":"Tetsuya","family":"Tsukamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0578"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.90.251"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0462-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.187"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24591"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-0876-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8230815"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02459.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12132"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0335-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0479-y"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02360.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(03)02159-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0041-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0357-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.4836"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000335260"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.16-43"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0764-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5009\/gnl14416"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00833.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12503"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28219"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0142-7"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.077776"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.4236\/ojpathology.2016.62012"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496692","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:11:36Z","timestamp":1745424696000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000496692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":28,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2019,6,6]]},"published-print":{"date-parts":[[2019,6,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000496692","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"value":"1015-2008","type":"print"},{"value":"1423-0291","type":"electron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