{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T07:59:05Z","timestamp":1775721545506,"version":"3.50.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Objectives:<\/i><\/b> The purpose of the study was to compare the efficacy of a product containing cranberry and propolis (DUAB) to placebo for reducing frequency of cystitis in women with recurrent acute cystitis. <b><i>Method:<\/i><\/b> A multicenter, placebo-controlled, randomized study of women aged &#x3e;18 years with at least 4 episodes of cystitis in the previous 12 months was performed. The number of cystitis episodes over a 6-month follow-up was the primary end point. <b><i>Results:<\/i><\/b> Forty-two women were included in the cranberry + propolis group, and 43 women were in the placebo group. The mean age was 53 \u00b1 18 years, with 6.2 \u00b1 3.6 cystitis episodes in the previous year, with no differences between the 2 groups.\u00a0The mean number of infections was lower in the propolis + cranberry group (respectively, 2.3 \u00b1 1.8 vs. 3.1 \u00b1 1.8). The total number of cystitis episodes in the first 3 months was lower in the propolis + cranberry group (0.7 \u00b1 1.1 vs. 1.3 \u00b1 1.1, <i>p<\/i> = 0.0257) after adjusting for water consumption. The mean time to onset of the first urinary tract infection (UTI) was also significantly longer in the propolis + cranberry group (69.9 \u00b1 45.8 days vs. 43.3 \u00b1 45.9, <i>p<\/i> = 0.0258). Tolerance to the treatments was good and comparable in both groups. <b><i>Conclusions:<\/i><\/b> We demonstrate for the first time that cranberry and propolis supplementation significantly reduces the incidence of UTIs during the first 3 months and delays the onset of an episode of cystitis.<\/jats:p>","DOI":"10.1159\/000496695","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T21:01:42Z","timestamp":1558558902000},"page":"41-48","source":"Crossref","is-referenced-by-count":26,"title":["A Multicenter, Randomized, Placebo-Controlled Study Evaluating the Efficacy of a Combination of Propolis and Cranberry (<b><i>Vaccinium macrocarpon<\/i><\/b>) (DUAB\u00ae) in Preventing Low Urinary Tract Infection Recurrence in Women Complaining of Recurrent Cystitis"],"prefix":"10.1159","volume":"103","author":[{"given":"Franck","family":"Bruy\u00e8re","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel\u00a0Rahm\u00e8ne","family":"Azzouzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Philippe","family":"Lavigne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Droupy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Coloby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Game","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Karsenty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Issartel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Ruffion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Misrai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Sotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois-Andr\u00e9","family":"Allaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,5,22]]},"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496695","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:11:38Z","timestamp":1745424698000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000496695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,7,12]]},"published-print":{"date-parts":[[2019,7,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000496695","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}