{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:39:16Z","timestamp":1770989956417,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Rapid drug desensitization (RDD) induces a temporary tolerance to chemotherapeutics that induce hypersensitivity reactions (HSRs). <b><i>Purpose:<\/i><\/b> Our objective is to report our experience with RDD to platins, taxanes, etoposide, doxorubicin, and irinotecan. <b><i>Methods:<\/i><\/b> The study was conducted as a retrospective chart review of patients with symptoms of HSRs to chemotherapeutics. HSRs were classified as grade I, II, or III, based on their severity. Skin prick\/intradermal tests were performed with implicated chemotherapeutics. A 12-step RDD protocol was used. <b><i>Results:<\/i><\/b> The study consisted of 38 women and 3 men (mean age 53.3 \u00b1 11.6 years). Patients had ovarian (<i>n<\/i> = 13, 31.8%), breast (<i>n<\/i> = 10, 24.4%), colon (<i>n<\/i> = 7, 17%), lung (<i>n<\/i> = 4, 9.8%), and other cancers (<i>n<\/i> = 7; endometrial sarcoma, testicular cancer, uterine cancer, ampulla of Vater tumor, choledochal tumor, peritonitis carcinomatosa, and Merkel cell carcinoma, <i>n<\/i> = 1, respectively). Twenty-two patients experienced HSRs to platins, 15 to taxanes, and 4 to other chemotherapeutics (doxorubicin, irinotecan, and etoposide). A total of 122 RDDs (47 to platins, 52 to taxanes, 23 to other chemotherapeutics) were performed. In 25 (61%) patients no reactions occurred during RDD, but breakthrough reactions developed in 16 patients (39%) with platins (<i>n<\/i> = 11), taxanes (<i>n<\/i> = 3), doxorubicin (<i>n<\/i> = 1), and irinotecan (<i>n<\/i> = 1). RDD procedures could not be completed in only 2 patients with grade II breakthrough reactions to carboplatin and oxaliplatin. <b><i>Conclusion:<\/i><\/b> In our experience, 98.3% of 122 RDDs were completed. We found that RDD was safe and effective in this the largest series of RDD with chemotherapeutics in our country.<\/jats:p>","DOI":"10.1159\/000496745","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T22:00:32Z","timestamp":1553119232000},"page":"114-122","source":"Crossref","is-referenced-by-count":27,"title":["Rapid Drug Desensitization with Chemotherapeutics (Platins, Taxanes, and Others): A Single-Center Retrospective Study"],"prefix":"10.1159","volume":"179","author":[{"given":"Re\u015fat","family":"Kendirlinan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-5917","authenticated-orcid":false,"given":"Reyhan","family":"G\u00fcm\u00fc\u015fburun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamir","family":"\u00c7er\u00e7i","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"\u00d6zbek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"Alt\u0131ner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"\u00c7elebi\u00a0S\u00f6zener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eadan","family":"Soyyi\u011fit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6m\u00fcr","family":"Ayd\u0131n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevim","family":"Bavbek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.04.012"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-1-66"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1111"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.044"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.009"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/all.12105"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.01.009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000454808"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.04.029"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000335637"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60247-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/1120009X.1989.11738916"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.03.002"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00201"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.539"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.06.002"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.10.010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.12.019"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-014-8416-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.06.028"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0453-5"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496745","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:12:07Z","timestamp":1745424727000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000496745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,5,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000496745","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}