{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:46:44Z","timestamp":1779270404777,"version":"3.51.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Introduction:<\/i><\/b> Women with von Willebrand disease (VWD) are at a higher risk of bleeding, which might affect the health of mother and child during pregnancy and the intra- and postpartum periods. This retrospective cohort study evaluates changes in the coagulation parameters von Willebrand factor antigen (VWF:Ag), von Willebrand ristocetin cofactor (VWF:RCo), and Factor VIII activity (FVIII:C) during pregnancy in patients with VWD. In total, 44 pregnancies of 38 patients were assessed (VWD type 1 <i>n<\/i> = 32, type 2A <i>n<\/i> = 3, type 2B <i>n<\/i> = 1, type 2 subtype unidentified <i>n<\/i> = 2). The patients\u2019 median age at childbirth was 32 years (range 22\u201340). <b><i>Results:<\/i><\/b> A significant increase in coagulation parameters was found in patients with VWD type 1 (VWF:Ag, VWF:RCo, and FVIII:C <i>p<\/i> = 0.000). In the third trimester, VWF:Ag and FVIII:C normalized in all patients with VWD type 1; in 3 patients VWF:RCo remained below the normal range. Patients with VWD type 2 showed a significant increase of VWF:Ag (<i>p<\/i> = 0.003) and FVIII:C (<i>p<\/i> = 0.011), and a non-significant increase of VWF:RCo (<i>p<\/i> = 0.097). In 4 of 9 pregnancies of patients with VWD type 2, all surveyed coagulation parameters normalized until the third trimester. <b><i>Conclusion:<\/i><\/b> For the majority of the observed patients, the von Willebrand parameters increased during pregnancy.<\/jats:p>","DOI":"10.1159\/000496820","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T21:00:57Z","timestamp":1557867657000},"page":"71-78","source":"Crossref","is-referenced-by-count":22,"title":["The Course of von Willebrand Factor and Factor VIII Activity in Patients with von Willebrand Disease during Pregnancy"],"prefix":"10.1159","volume":"142","author":[{"given":"Christiane","family":"Delbr\u00fcck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4506-0061","authenticated-orcid":false,"given":"Wolfgang","family":"Miesbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-165621"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.077263"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.03.012"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38897"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03975.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02625.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2016.11.012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112935"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12664"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12586"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3283566af9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02563.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12568"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.1995.tb00056.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000438961.38979.19"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.011239"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040403"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2013.052"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:12:53Z","timestamp":1745424773000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000496820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,8,5]]},"published-print":{"date-parts":[[2019,8,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000496820","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}