{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:20:39Z","timestamp":1790828439686,"version":"4.1.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Sacrococcygeal teratomas (SCT) are often highly vascularized and may result in high-output cardiac failure, polyhydramnios, fetal hydrops, and demise. Delivery is guided by the SCT to fetus volume ratio (SCTratio), SCT growth rate, and cardiac output indexed for weight (CCOi). <b><i>Methods:<\/i><\/b> We compared measurements and outcome in 12 consecutive fetuses referred with SCT. Adverse outcomes were: fetal surgery, delivery &#x3c; 32 gestational weeks or neonatal demise. Only SCTratio and CCOi were used to manage the cases. SCT vascularization index (VI%) was derived from the 3D virtual organ computer-aided analysis (VOCAL) software. The SCTModel (modified from acardiac twins) calculated a hypothetical SCT draining vein size and derived a risk line, using diameters of the superior and inferior vena cava, the azygous and umbilical veins. VI% and a model of systemic and umbilical venous volumes (SCTModel) were tested as indicators for outcome in SCT. <b><i>Results:<\/i><\/b> Fetuses were monitored from 20.1 to 36.4 gestational weeks and 5\/12 had adverse outcomes: 1 had successful open fetal surgery at 23.8 weeks and delivered at term, 4 delivered at &#x3c; 32 weeks with 3\/4 having neonatal demise between 25 and 29 weeks. VI% was significantly higher in cases with adverse outcomes (mean 10.3 [8.9\u201311.6] vs. 4.4 [3.4\u20135.3], <i>p<\/i> &#x3c; 0.0001). The additional fraction of the fetal cardiac output required to perfuse the SCT-draining vein (XSCO%) (<i>p<\/i> = 0.46), SCTratio (<i>p<\/i> = 0.08), and CCOi (<i>p<\/i> = 0.64) were not significant. All cases with adverse outcome had VI% &#x3e; 8%. The SCTModel risk line predicted nonadverse outcomes well but lacked data in 2\/5 cases with adverse outcomes. <b><i>Conclusions:<\/i><\/b> VI% is a significant indicator of SCT cases with adverse outcomes and combined with SCTratio may guide timing of delivery better than current measures.<\/jats:p>","DOI":"10.1159\/000496841","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T22:00:32Z","timestamp":1553119232000},"page":"333-340","source":"Crossref","is-referenced-by-count":24,"title":["Clinical Monitoring of Sacrococcygeal Teratoma"],"prefix":"10.1159","volume":"46","author":[{"given":"Christoph","family":"Wohlmuth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth\u00a0J.","family":"Moise\u00a0Jr.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin\u00a0J.C.","family":"van\u00a0Gemert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen\u00a0P.H.M.","family":"van\u00a0den\u00a0Wijngaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Wohlmuth-Wieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Averiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena\u00a0M.","family":"Gardiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(74)80297-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90177-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.07.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13315"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.11.005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.10.020"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80456-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000074257"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(90)90535-H"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.03.051"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.05.029"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000188056"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.12.1662"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12309"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.04.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23531"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23467"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.08.002"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9000"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.02.034"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000486782"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000330762"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/496841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:13:08Z","timestamp":1745424788000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000496841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,11,13]]},"published-print":{"date-parts":[[2019,11,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000496841","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.7868261","asserted-by":"subject"}]},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}